Critical role for cholesterol in Lassa fever virus entry identified by a novel small molecule inhibitor targeting the viral receptor LAMP1

Lassa fever virus (LASV) is endemic in West Africa and causes severe hemorrhagic fever and sensorineural hearing loss. We identified a small molecule inhibitor of LASV and used it to analyze the mechanism of entry. Using a photo-reactive analog that retains antiviral activity as a probe, we identifi...

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Detalles Bibliográficos
Autores principales: Wang, May Kwang-Mei, Ren, Tao, Liu, Hu, Lim, Sun-Young, Lee, Kyungae, Honko, Anna, Zhou, Huanying, Dyall, Julie, Hensley, Lisa, Gartin, Ashley K., Cunningham, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179309/
https://www.ncbi.nlm.nih.gov/pubmed/30265711
http://dx.doi.org/10.1371/journal.ppat.1007322

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