Cryo-EM structure of P. falciparum circumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts

The circumsporozoite protein (CSP) on the surface of Plasmodium falciparum sporozoites is important for parasite development, motility, and host hepatocyte invasion. However, intrinsic disorder of the NANP repeat sequence in the central region of CSP has hindered its structural and functional charac...

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Detalles Bibliográficos
Autores principales: Oyen, David, Torres, Jonathan L., Cottrell, Christopher A., Richter King, C., Wilson, Ian A., Ward, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179375/
https://www.ncbi.nlm.nih.gov/pubmed/30324137
http://dx.doi.org/10.1126/sciadv.aau8529

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