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Promoting vascular healing using nanofibrous ticagrelor-eluting stents

OBJECTIVE: The current treatment of atherosclerotic coronary heart disease with limus-eluting stents can lead to incomplete endothelialization and substantial impairment of arterial healing relative to treatment with bare-metal stents. The sustained and local delivery of ticagrelor, a reversibly bin...

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Autores principales: Lee, Cheng-Hung, Hsieh, Ming-Jer, Liu, Kuo-Sheng, Cheng, Che-Wei, Chang, Shang-Hung, Liu, Shih-Jung, Wang, Chao-Jan, Hsu, Ming-Yi, Hung, Kuo-Chun, Yeh, Yung-Hsin, Chen, Wei-Jan, Hsieh, I-Chang, Juang, Jyuhn-Huarng, Wen, Ming-Shien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179723/
https://www.ncbi.nlm.nih.gov/pubmed/30323591
http://dx.doi.org/10.2147/IJN.S166785
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author Lee, Cheng-Hung
Hsieh, Ming-Jer
Liu, Kuo-Sheng
Cheng, Che-Wei
Chang, Shang-Hung
Liu, Shih-Jung
Wang, Chao-Jan
Hsu, Ming-Yi
Hung, Kuo-Chun
Yeh, Yung-Hsin
Chen, Wei-Jan
Hsieh, I-Chang
Juang, Jyuhn-Huarng
Wen, Ming-Shien
author_facet Lee, Cheng-Hung
Hsieh, Ming-Jer
Liu, Kuo-Sheng
Cheng, Che-Wei
Chang, Shang-Hung
Liu, Shih-Jung
Wang, Chao-Jan
Hsu, Ming-Yi
Hung, Kuo-Chun
Yeh, Yung-Hsin
Chen, Wei-Jan
Hsieh, I-Chang
Juang, Jyuhn-Huarng
Wen, Ming-Shien
author_sort Lee, Cheng-Hung
collection PubMed
description OBJECTIVE: The current treatment of atherosclerotic coronary heart disease with limus-eluting stents can lead to incomplete endothelialization and substantial impairment of arterial healing relative to treatment with bare-metal stents. The sustained and local delivery of ticagrelor, a reversibly binding P2Y12 receptor inhibitor, using hybrid biodegradable nanofibers/stents, was developed to reduce neointimal formation and endothelial dysfunction. METHODS: In this investigation, a solution of ticagrelor, poly(D,L)-lactide-co-glycolide, and hexafluoro isopropanol was electrospun to fabricate ticagrelor-eluting nanofibrous drug-eluting stents. The in vitro and in vivo ticagrelor concentrations were measured using a high-performance liquid chromatography assay. The effectiveness of ticagrelor-eluting stents was examined relative to that of sirolimus-eluting stents. RESULTS: Adequate ticagrelor levels were detected for four weeks in vitro. Less HES5-positive labeling was found near the ticagrelor-eluting stented vessels (0.33±0.12) than close to the sirolimus-eluting stented vessels (0.57±0.15) (p<0.05). Four weeks after deployment, the ticagrelor-eluting stent also exhibited an up-regulated local expression of SOD1 in the stenting area (p<0.001). The ticagrelor-eluting stent substantially preserved endothelial function and re-endothelialization, minimized inflammatory responses, and inhibited neointimal hyperplasia. CONCLUSION: Ticagrelor-eluting stents may provide an alternative route for treating patients at a high risk of bleeding to preserve endothelial recovery and to reduce smooth muscle proliferation.
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spelling pubmed-61797232018-10-15 Promoting vascular healing using nanofibrous ticagrelor-eluting stents Lee, Cheng-Hung Hsieh, Ming-Jer Liu, Kuo-Sheng Cheng, Che-Wei Chang, Shang-Hung Liu, Shih-Jung Wang, Chao-Jan Hsu, Ming-Yi Hung, Kuo-Chun Yeh, Yung-Hsin Chen, Wei-Jan Hsieh, I-Chang Juang, Jyuhn-Huarng Wen, Ming-Shien Int J Nanomedicine Original Research OBJECTIVE: The current treatment of atherosclerotic coronary heart disease with limus-eluting stents can lead to incomplete endothelialization and substantial impairment of arterial healing relative to treatment with bare-metal stents. The sustained and local delivery of ticagrelor, a reversibly binding P2Y12 receptor inhibitor, using hybrid biodegradable nanofibers/stents, was developed to reduce neointimal formation and endothelial dysfunction. METHODS: In this investigation, a solution of ticagrelor, poly(D,L)-lactide-co-glycolide, and hexafluoro isopropanol was electrospun to fabricate ticagrelor-eluting nanofibrous drug-eluting stents. The in vitro and in vivo ticagrelor concentrations were measured using a high-performance liquid chromatography assay. The effectiveness of ticagrelor-eluting stents was examined relative to that of sirolimus-eluting stents. RESULTS: Adequate ticagrelor levels were detected for four weeks in vitro. Less HES5-positive labeling was found near the ticagrelor-eluting stented vessels (0.33±0.12) than close to the sirolimus-eluting stented vessels (0.57±0.15) (p<0.05). Four weeks after deployment, the ticagrelor-eluting stent also exhibited an up-regulated local expression of SOD1 in the stenting area (p<0.001). The ticagrelor-eluting stent substantially preserved endothelial function and re-endothelialization, minimized inflammatory responses, and inhibited neointimal hyperplasia. CONCLUSION: Ticagrelor-eluting stents may provide an alternative route for treating patients at a high risk of bleeding to preserve endothelial recovery and to reduce smooth muscle proliferation. Dove Medical Press 2018-10-05 /pmc/articles/PMC6179723/ /pubmed/30323591 http://dx.doi.org/10.2147/IJN.S166785 Text en © 2018 Lee et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Lee, Cheng-Hung
Hsieh, Ming-Jer
Liu, Kuo-Sheng
Cheng, Che-Wei
Chang, Shang-Hung
Liu, Shih-Jung
Wang, Chao-Jan
Hsu, Ming-Yi
Hung, Kuo-Chun
Yeh, Yung-Hsin
Chen, Wei-Jan
Hsieh, I-Chang
Juang, Jyuhn-Huarng
Wen, Ming-Shien
Promoting vascular healing using nanofibrous ticagrelor-eluting stents
title Promoting vascular healing using nanofibrous ticagrelor-eluting stents
title_full Promoting vascular healing using nanofibrous ticagrelor-eluting stents
title_fullStr Promoting vascular healing using nanofibrous ticagrelor-eluting stents
title_full_unstemmed Promoting vascular healing using nanofibrous ticagrelor-eluting stents
title_short Promoting vascular healing using nanofibrous ticagrelor-eluting stents
title_sort promoting vascular healing using nanofibrous ticagrelor-eluting stents
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179723/
https://www.ncbi.nlm.nih.gov/pubmed/30323591
http://dx.doi.org/10.2147/IJN.S166785
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