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Schizophrenia moderates the relationship between white matter integrity and cognition
Cognitive impairment is a primary feature of schizophrenia, with alterations in several cognitive domains appearing in the pre-morbid phase of the disorder. White matter microstructure is also affected in schizophrenia and considered to be related to cognition, but the relationship of the two is unc...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science Publisher B. V
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179965/ https://www.ncbi.nlm.nih.gov/pubmed/29602641 http://dx.doi.org/10.1016/j.schres.2018.03.033 |
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author | Castro-de-Araujo, Luis F.S. Allin, Mathew Picchioni, Marco M. Mcdonald, Colm Pantelis, Christos Kanaan, Richard A.A. |
author_facet | Castro-de-Araujo, Luis F.S. Allin, Mathew Picchioni, Marco M. Mcdonald, Colm Pantelis, Christos Kanaan, Richard A.A. |
author_sort | Castro-de-Araujo, Luis F.S. |
collection | PubMed |
description | Cognitive impairment is a primary feature of schizophrenia, with alterations in several cognitive domains appearing in the pre-morbid phase of the disorder. White matter microstructure is also affected in schizophrenia and considered to be related to cognition, but the relationship of the two is unclear. As interaction between cognition and white matter structure involves the interplay of several brain structures and cognitive abilities, investigative methods which can examine the interaction of multiple variables are preferred. A multiple-groups structural equation model (SEM) was used to assess the relationship between diffusion tension imaging data (fractional anisotropy of selected white matter tracts) and cognitive abilities of 196 subjects - 135 healthy subjects and 61 patients with schizophrenia. It was found that multiple-indicators, multiple-causes model best fitted the data analysed. Schizophrenia moderated the relation of white matter function on cognition with a large effect size. This paper extends previous work on modelling intelligence within a SEM framework by incorporating neurological elements into the model, and shows that white matter microstructure in patients with schizophrenia interacts with cognitive abilities. |
format | Online Article Text |
id | pubmed-6179965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier Science Publisher B. V |
record_format | MEDLINE/PubMed |
spelling | pubmed-61799652018-10-12 Schizophrenia moderates the relationship between white matter integrity and cognition Castro-de-Araujo, Luis F.S. Allin, Mathew Picchioni, Marco M. Mcdonald, Colm Pantelis, Christos Kanaan, Richard A.A. Schizophr Res Article Cognitive impairment is a primary feature of schizophrenia, with alterations in several cognitive domains appearing in the pre-morbid phase of the disorder. White matter microstructure is also affected in schizophrenia and considered to be related to cognition, but the relationship of the two is unclear. As interaction between cognition and white matter structure involves the interplay of several brain structures and cognitive abilities, investigative methods which can examine the interaction of multiple variables are preferred. A multiple-groups structural equation model (SEM) was used to assess the relationship between diffusion tension imaging data (fractional anisotropy of selected white matter tracts) and cognitive abilities of 196 subjects - 135 healthy subjects and 61 patients with schizophrenia. It was found that multiple-indicators, multiple-causes model best fitted the data analysed. Schizophrenia moderated the relation of white matter function on cognition with a large effect size. This paper extends previous work on modelling intelligence within a SEM framework by incorporating neurological elements into the model, and shows that white matter microstructure in patients with schizophrenia interacts with cognitive abilities. Elsevier Science Publisher B. V 2018-09 /pmc/articles/PMC6179965/ /pubmed/29602641 http://dx.doi.org/10.1016/j.schres.2018.03.033 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Castro-de-Araujo, Luis F.S. Allin, Mathew Picchioni, Marco M. Mcdonald, Colm Pantelis, Christos Kanaan, Richard A.A. Schizophrenia moderates the relationship between white matter integrity and cognition |
title | Schizophrenia moderates the relationship between white matter integrity and cognition |
title_full | Schizophrenia moderates the relationship between white matter integrity and cognition |
title_fullStr | Schizophrenia moderates the relationship between white matter integrity and cognition |
title_full_unstemmed | Schizophrenia moderates the relationship between white matter integrity and cognition |
title_short | Schizophrenia moderates the relationship between white matter integrity and cognition |
title_sort | schizophrenia moderates the relationship between white matter integrity and cognition |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179965/ https://www.ncbi.nlm.nih.gov/pubmed/29602641 http://dx.doi.org/10.1016/j.schres.2018.03.033 |
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