Structural insights on TRPV5 gating by endogenous modulators

TRPV5 is a transient receptor potential channel involved in calcium reabsorption. Here we investigate the interaction of two endogenous modulators with TRPV5. Both phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) and calmodulin (CaM) have been shown to directly bind to TRPV5 and activate or inact...

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Detalles Bibliográficos
Autores principales: Hughes, Taylor E. T., Pumroy, Ruth A., Yazici, Aysenur Torun, Kasimova, Marina A., Fluck, Edwin C., Huynh, Kevin W., Samanta, Amrita, Molugu, Sudheer K., Zhou, Z. Hong, Carnevale, Vincenzo, Rohacs, Tibor, Moiseenkova-Bell, Vera Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179994/
https://www.ncbi.nlm.nih.gov/pubmed/30305626
http://dx.doi.org/10.1038/s41467-018-06753-6

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