Loss of complex O-glycosylation impairs exocrine pancreatic function and induces MODY8-like diabetes in mice

Cosmc is ubiquitously expressed and acts as a specific molecular chaperone assisting the folding and stability of core 1 synthase. Thus, it plays a crucial role in the biosynthesis of O-linked glycosylation of proteins. Here, we show that ablation of Cosmc in the exocrine pancreas of mice causes exp...

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Detalles Bibliográficos
Autores principales: Wolters-Eisfeld, Gerrit, Mercanoglu, Baris, Hofmann, Bianca T., Wolpers, Thomas, Schnabel, Claudia, Harder, Sönke, Steffen, Pascal, Bachmann, Kai, Steglich, Babett, Schrader, Jörg, Gagliani, Nicola, Schlüter, Hartmut, Güngör, Cenap, Izbicki, Jakob R., Wagener, Christoph, Bockhorn, Maximilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180059/
https://www.ncbi.nlm.nih.gov/pubmed/30305605
http://dx.doi.org/10.1038/s12276-018-0157-3

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