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Structural basis for PtdInsP(2)-mediated human TRPML1 regulation

Transient receptor potential mucolipin 1 (TRPML1), a lysosomal channel, maintains the low pH and calcium levels for lysosomal function. Several small molecules modulate TRPML1 activity. ML-SA1, a synthetic agonist, binds to the pore region and phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P(2)),...

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Detalles Bibliográficos
Autores principales:	Fine, Michael, Schmiege, Philip, Li, Xiaochun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180102/ https://www.ncbi.nlm.nih.gov/pubmed/30305615 http://dx.doi.org/10.1038/s41467-018-06493-7

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