Cargando…

Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational Modelling

Atrial fibrillation (AF) and sinus bradycardia have been reported in patients with short QT syndrome variant 2 (SQT2), which is underlain by gain-of-function mutations in KCNQ1 encoding the α subunit of channels carrying slow delayed rectifier potassium current, I(Ks). However, the mechanism(s) unde...

Descripción completa

Detalles Bibliográficos
Autores principales:	Whittaker, Dominic G., Colman, Michael A., Ni, Haibo, Hancox, Jules C., Zhang, Henggui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180159/ https://www.ncbi.nlm.nih.gov/pubmed/30337886 http://dx.doi.org/10.3389/fphys.2018.01402

Ejemplares similares

In silico Assessment of Pharmacotherapy for Human Atrial Patho-Electrophysiology Associated With hERG-Linked Short QT Syndrome
por: Whittaker, Dominic G., et al.
Publicado: (2019)

Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles
por: Whittaker, Dominic G., et al.
Publicado: (2017)

In silico investigation of a KCNQ1 mutation associated with short QT syndrome
por: Adeniran, Ismail, et al.
Publicado: (2017)

Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria
por: Whittaker, Dominic G., et al.
Publicado: (2017)

In silico investigation of the short QT syndrome, using human ventricle models incorporating electromechanical coupling
por: Adeniran, Ismail, et al.
Publicado: (2013)

In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis
por: Colman, Michael A., et al.
Publicado: (2017)

Morphological Substrates for Atrial Arrhythmogenesis in a Heart With Atrioventricular Septal Defect
por: Stephenson, Robert S., et al.
Publicado: (2018)

Computational Cardiac Modeling Reveals Mechanisms of Ventricular Arrhythmogenesis in Long QT Syndrome Type 8: CACNA1C R858H Mutation Linked to Ventricular Fibrillation
por: Bai, Jieyun, et al.
Publicado: (2017)

Electrophysiological Mechanisms Underlying T-Wave Alternans and Their Role in Arrhythmogenesis
por: You, Tingting, et al.
Publicado: (2021)

Influence of the KCNQ1 S140G Mutation on Human Ventricular Arrhythmogenesis and Pumping Performance: Simulation Study
por: Jeong, Da Un, et al.
Publicado: (2018)

Increased Vulnerability of Human Ventricle to Re-entrant Excitation in hERG-linked Variant 1 Short QT Syndrome
por: Adeniran, Ismail, et al.
Publicado: (2011)

Mechanistic Insights Into the Reduced Pacemaking Rate of the Rabbit Sinoatrial Node During Postnatal Development: A Simulation Study
por: Alghamdi, Azzah M., et al.
Publicado: (2020)

Abnormal Ca(2+) homeostasis, atrial arrhythmogenesis, and sinus node dysfunction in murine hearts modeling RyR2 modification
por: Zhang, Yanmin, et al.
Publicado: (2013)

Pharmacological rescue of specific long QT variants of KCNQ1/KCNE1 channels
por: Zou, Xinle, et al.
Publicado: (2022)

Identification through action potential clamp of proarrhythmic consequences of the short QT syndrome T618I hERG ‘hotspot’ mutation
por: Du, Chunyun, et al.
Publicado: (2022)

Long QT Syndrome and Sinus Bradycardia–A Mini Review
por: Wilders, Ronald, et al.
Publicado: (2018)

Pro-Arrhythmic Effects of Discontinuous Conduction at the Purkinje Fiber-Ventricle Junction Arising From Heart Failure-Induced Ionic Remodeling – Insights From Computational Modelling
por: Jian, Kun, et al.
Publicado: (2022)

Cardiac Macrophages and Their Effects on Arrhythmogenesis
por: Xia, Ruibing, et al.
Publicado: (2022)

Editorial: Transcription factors and arrhythmogenesis
por: Kao, Yu-Hsun, et al.
Publicado: (2023)

Action Potential Clamp and Pharmacology of the Variant 1 Short QT Syndrome T618I hERG K(+) Channel
por: El Harchi, Aziza, et al.
Publicado: (2012)

Synergistic Anti-arrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin
por: Ni, Haibo, et al.
Publicado: (2017)

Reactive Oxygen Species, Endoplasmic Reticulum Stress and Mitochondrial Dysfunction: The Link with Cardiac Arrhythmogenesis
por: Tse, Gary, et al.
Publicado: (2016)

Atrial GIRK Channels Mediate the Effects of Vagus Nerve Stimulation on Heart Rate Dynamics and Arrhythmogenesis
por: Lee, Steven W., et al.
Publicado: (2018)

T-Wave Alternans and Arrhythmogenesis in Cardiac Diseases
por: Qu, Zhilin, et al.
Publicado: (2010)

Sex Differences in Drug-Induced Arrhythmogenesis
por: Peirlinck, Mathias, et al.
Publicado: (2021)

Abnormal calcium homeostasis in heart failure with preserved ejection fraction is related to both reduced contractile function and incomplete relaxation: an electromechanically detailed biophysical modeling study
por: Adeniran, Ismail, et al.
Publicado: (2015)

Cardiac Pacemaker Dysfunction Arising From Different Studies of Ion Channel Remodeling in the Aging Rat Heart
por: Alghamdi, Aaazh M., et al.
Publicado: (2020)

Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome
por: El Harchi, Aziza, et al.
Publicado: (2009)

Ion channels, long QT syndrome and arrhythmogenesis in ageing
por: Jeevaratnam, Kamalan, et al.
Publicado: (2017)

Electromechanical reciprocity and arrhythmogenesis in long-QT syndrome and beyond( )
por: Odening, Katja E, et al.
Publicado: (2022)

The Functional Role of Hyperpolarization Activated Current (I(f)) on Cardiac Pacemaking in Human vs. in the Rabbit Sinoatrial Node: A Simulation and Theoretical Study
por: Bai, Xiangyun, et al.
Publicado: (2021)

Role of the intercalated disc in cardiac propagation and arrhythmogenesis
por: Kleber, Andre G., et al.
Publicado: (2014)

Determinants of myocardial conduction velocity: implications for arrhythmogenesis
por: King, James H., et al.
Publicado: (2013)

Modelling the effects of chloroquine on KCNJ2-linked short QT syndrome
por: Luo, Cunjin, et al.
Publicado: (2017)

Investigation of the Effects of the Short QT Syndrome D172N Kir2.1 Mutation on Ventricular Action Potential Profile Using Dynamic Clamp
por: Du, Chunyun, et al.
Publicado: (2022)

A novel variant in KCNQ1 associated with short QT syndrome
por: Schneider, Kristin, et al.
Publicado: (2021)

Electrophysiological Mechanisms of Gastrointestinal Arrhythmogenesis: Lessons from the Heart
por: Tse, Gary, et al.
Publicado: (2016)

Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the Mouse
por: Edwards, Andrew G., et al.
Publicado: (2021)

Fatty Infiltration of the Myocardium and Arrhythmogenesis: Potential Cellular and Molecular Mechanisms
por: Anumonwo, Justus M. B., et al.
Publicado: (2018)

Artificial intelligence analysis of the impact of fibrosis in arrhythmogenesis and drug response
por: Sánchez de la Nava, Ana María, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mn3u3fpdf2krn2j44462m7f4e4