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Audiovisual Integration Enhances Stimulus Detection Performance in Mice
The detection of objects in the external world improves when humans and animals integrate object features of multiple sensory modalities. Behavioral and neuronal mechanisms underlying multisensory stimulus detection are poorly understood, mainly because they have not been investigated with suitable...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180166/ https://www.ncbi.nlm.nih.gov/pubmed/30337861 http://dx.doi.org/10.3389/fnbeh.2018.00231 |
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author | Meijer, Guido T. Pie, Jean L. Dolman, Thomas L. Pennartz, Cyriel M. A. Lansink, Carien S. |
author_facet | Meijer, Guido T. Pie, Jean L. Dolman, Thomas L. Pennartz, Cyriel M. A. Lansink, Carien S. |
author_sort | Meijer, Guido T. |
collection | PubMed |
description | The detection of objects in the external world improves when humans and animals integrate object features of multiple sensory modalities. Behavioral and neuronal mechanisms underlying multisensory stimulus detection are poorly understood, mainly because they have not been investigated with suitable behavioral paradigms. Such behavioral paradigms should (i) elicit a robust multisensory gain, (ii) incorporate systematic calibration of stimulus amplitude to the sensory capacities of the individual subject, (iii) yield a high trial count, and (iv) be easily compatible with a large variety of neurophysiological recording techniques. We developed an audiovisual stimulus detection task for head-fixed mice which meets all of these critical behavioral constraints. Behavioral data obtained with this task indicated a robust increase in detection performance of multisensory stimuli compared with unisensory cues, which was maximal when both stimulus constituents were presented at threshold intensity. The multisensory behavioral effect was associated with a change in the perceptual performance which consisted of two components. First, the visual and auditory perceptual systems increased their sensitivity meaning that low intensity stimuli were more often detected. Second, enhanced acuity enabled the systems to better classify whether there was a stimulus or not. Fitting our data to signal detection models revealed that the multisensory gain was more likely to be achieved by integration of sensory signals rather than by stimulus redundancy or competition. This validated behavioral paradigm can be exploited to reliably investigate the neuronal correlates of multisensory stimulus detection at the level of single neurons, microcircuits, and larger perceptual systems. |
format | Online Article Text |
id | pubmed-6180166 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61801662018-10-18 Audiovisual Integration Enhances Stimulus Detection Performance in Mice Meijer, Guido T. Pie, Jean L. Dolman, Thomas L. Pennartz, Cyriel M. A. Lansink, Carien S. Front Behav Neurosci Behavioral Neuroscience The detection of objects in the external world improves when humans and animals integrate object features of multiple sensory modalities. Behavioral and neuronal mechanisms underlying multisensory stimulus detection are poorly understood, mainly because they have not been investigated with suitable behavioral paradigms. Such behavioral paradigms should (i) elicit a robust multisensory gain, (ii) incorporate systematic calibration of stimulus amplitude to the sensory capacities of the individual subject, (iii) yield a high trial count, and (iv) be easily compatible with a large variety of neurophysiological recording techniques. We developed an audiovisual stimulus detection task for head-fixed mice which meets all of these critical behavioral constraints. Behavioral data obtained with this task indicated a robust increase in detection performance of multisensory stimuli compared with unisensory cues, which was maximal when both stimulus constituents were presented at threshold intensity. The multisensory behavioral effect was associated with a change in the perceptual performance which consisted of two components. First, the visual and auditory perceptual systems increased their sensitivity meaning that low intensity stimuli were more often detected. Second, enhanced acuity enabled the systems to better classify whether there was a stimulus or not. Fitting our data to signal detection models revealed that the multisensory gain was more likely to be achieved by integration of sensory signals rather than by stimulus redundancy or competition. This validated behavioral paradigm can be exploited to reliably investigate the neuronal correlates of multisensory stimulus detection at the level of single neurons, microcircuits, and larger perceptual systems. Frontiers Media S.A. 2018-10-04 /pmc/articles/PMC6180166/ /pubmed/30337861 http://dx.doi.org/10.3389/fnbeh.2018.00231 Text en Copyright © 2018 Meijer, Pie, Dolman, Pennartz and Lansink. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Behavioral Neuroscience Meijer, Guido T. Pie, Jean L. Dolman, Thomas L. Pennartz, Cyriel M. A. Lansink, Carien S. Audiovisual Integration Enhances Stimulus Detection Performance in Mice |
title | Audiovisual Integration Enhances Stimulus Detection Performance in Mice |
title_full | Audiovisual Integration Enhances Stimulus Detection Performance in Mice |
title_fullStr | Audiovisual Integration Enhances Stimulus Detection Performance in Mice |
title_full_unstemmed | Audiovisual Integration Enhances Stimulus Detection Performance in Mice |
title_short | Audiovisual Integration Enhances Stimulus Detection Performance in Mice |
title_sort | audiovisual integration enhances stimulus detection performance in mice |
topic | Behavioral Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180166/ https://www.ncbi.nlm.nih.gov/pubmed/30337861 http://dx.doi.org/10.3389/fnbeh.2018.00231 |
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