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Parkin is a disease modifier in the mutant SOD1 mouse model of ALS

Mutant Cu/Zn superoxide dismutase (SOD1) causes mitochondrial alterations that contribute to motor neuron demise in amyotrophic lateral sclerosis (ALS). When mitochondria are damaged, cells activate mitochondria quality control (MQC) mechanisms leading to mitophagy. Here, we show that in the spinal...

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Detalles Bibliográficos
Autores principales:	Palomo, Gloria M, Granatiero, Veronica, Kawamata, Hibiki, Konrad, Csaba, Kim, Michelle, Arreguin, Andrea J, Zhao, Dazhi, Milner, Teresa A, Manfredi, Giovanni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180298/ https://www.ncbi.nlm.nih.gov/pubmed/30126943 http://dx.doi.org/10.15252/emmm.201808888

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