Cargando…
A central role for glial CCR5 in directing the neuropathological interactions of HIV-1 Tat and opiates
BACKGROUND: The collective cognitive and motor deficits known as HIV-associated neurocognitive disorders (HAND) remain high even among HIV+ individuals whose antiretroviral therapy is optimized. HAND is worsened in the context of opiate abuse. The mechanism of exacerbation remains unclear but likely...
Autores principales: | Kim, Sarah, Hahn, Yun Kyung, Podhaizer, Elizabeth M, McLane, Virginia D, Zou, Shiping, Hauser, Kurt F, Knapp, Pamela E |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180355/ https://www.ncbi.nlm.nih.gov/pubmed/30305110 http://dx.doi.org/10.1186/s12974-018-1320-4 |
Ejemplares similares
-
Opiate Addiction Therapies and HIV-1 Tat: Interactive Effects on Glial [Ca(2+)]i, Oxyradical and Neuroinflammatory Chemokine Production and Correlative Neurotoxicity
por: Fitting, Sylvia, et al.
Publicado: (2014) -
Opiate Drug Use and the Pathophysiology of NeuroAIDS
por: Hauser, Kurt F, et al.
Publicado: (2012) -
Opiate Drugs with Abuse Liability Hijack the Endogenous Opioid System to Disrupt Neuronal and Glial Maturation in the Central Nervous System
por: Hauser, Kurt F., et al.
Publicado: (2018) -
Effects of chronic HIV-1 Tat exposure in the CNS: heightened vulnerability of males versus females to changes in cell numbers, synaptic integrity, and behavior
por: Hahn, Yun Kyung, et al.
Publicado: (2013) -
Chronic HIV-1 Tat exposure alters anterior cingulate cortico-basal ganglia-thalamocortical synaptic circuitry, associated behavioral control, and immune regulation in male mice
por: Nass, Sara R., et al.
Publicado: (2020)