Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells

BACKGROUND: In the bone marrow, MSCs reside in a hypoxic milieu (1–5% O(2)) that is thought to preserve their multipotent state. Typically, in vitro expansion of MSCs is performed under normoxia (~ 21% O(2)), a process that has been shown to impair their function. Here, we evaluated the characterist...

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Detalles Bibliográficos
Autores principales: Antebi, Ben, Rodriguez, Luis A, Walker, Kerfoot P, Asher, Amber M, Kamucheka, Robin M, Alvarado, Lucero, Mohammadipoor, Arezoo, Cancio, Leopoldo C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180371/
https://www.ncbi.nlm.nih.gov/pubmed/30305185
http://dx.doi.org/10.1186/s13287-018-1007-x

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