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Optimization of fermentation conditions for an Escherichia coli strain engineered using the response surface method to produce a novel therapeutic DNA vaccine for rheumatoid arthritis

BACKGROUND: Fermentation condition optimization and nutrients screening are of equal importance for efficient production of plasmid DNA vaccines. This directly affects the downstream purification and final quality and yield of plasmid DNA vaccines. The present study aimed to optimize the fermentatio...

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Detalles Bibliográficos
Autores principales:	Long, Juan, Zhao, Xiao, Liang, Fei, Liu, Nan, Sun, Yuying, Xi, Yongzhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180442/ https://www.ncbi.nlm.nih.gov/pubmed/30337953 http://dx.doi.org/10.1186/s13036-018-0110-y

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