Choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial – the development of the DELTA(2) guidance

BACKGROUND: A key step in the design of a randomised controlled trial is the estimation of the number of participants needed. The most common approach is to specify a target difference in the primary outcome between the randomised groups and then estimate the corresponding sample size. The sample si...

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Detalles Bibliográficos
Autores principales: Sones, William, Julious, Steven A., Rothwell, Joanne C., Ramsay, Craig Robert, Hampson, Lisa V., Emsley, Richard, Walters, Stephen J., Hewitt, Catherine, Bland, Martin, Fergusson, Dean A., Berlin, Jesse A., Altman, Doug, Vale, Luke David, Cook, Jonathan Alistair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180499/
https://www.ncbi.nlm.nih.gov/pubmed/30305155
http://dx.doi.org/10.1186/s13063-018-2887-x

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