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Combined study on clastogenic, aneugenic and apoptotic properties of doxorubicin in human cells in vitro

BACKGROUND: Doxorubicin is a widely used anticancer drug due to its broad spectrum of antitumor activity. Various mechanisms have been proposed for its cytostatic activity, including DNA intercalation, topoisomerase II inhibition, generation of free radicals and apoptosis. The present study aims to...

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Detalles Bibliográficos
Autores principales:	Chondrou, Vasiliki, Trochoutsou, Katerina, Panayides, Andreas, Efthimiou, Maria, Stephanou, Georgia, Demopoulos, Nikos A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180587/ https://www.ncbi.nlm.nih.gov/pubmed/30338246 http://dx.doi.org/10.1186/s40709-018-0089-z

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