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Spontaneous seizure and partial lethality of juvenile Shank3-overexpressing mice in C57BL/6 J background
The SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene encodes core scaffolds in neuronal excitatory postsynapses. SHANK3 duplications have been identified in patients with hyperkinetic disorders and early-onset generalized tonic-clonic seizures. Consistently, Shank3 transgenic (TG) mice, which...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180595/ https://www.ncbi.nlm.nih.gov/pubmed/30305163 http://dx.doi.org/10.1186/s13041-018-0403-6 |