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Spontaneous seizure and partial lethality of juvenile Shank3-overexpressing mice in C57BL/6 J background

The SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene encodes core scaffolds in neuronal excitatory postsynapses. SHANK3 duplications have been identified in patients with hyperkinetic disorders and early-onset generalized tonic-clonic seizures. Consistently, Shank3 transgenic (TG) mice, which...

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Detalles Bibliográficos
Autores principales:	Jin, Chunmei, Zhang, Yinhua, Kim, Shinhyun, Kim, Yoonhee, Lee, Yeunkum, Han, Kihoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Micro Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180595/ https://www.ncbi.nlm.nih.gov/pubmed/30305163 http://dx.doi.org/10.1186/s13041-018-0403-6

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