The impact of p53 function on the metabolic activation of the carcinogenic air pollutant 3-nitrobenzanthrone and its metabolites 3-aminobenzanthrone and N-hydroxy-3-aminobenzanthrone in human cells

The tumour suppressor p53, encoded by TP53, is a key player in a wide network of signalling pathways. We investigated its role in the bioactivation of the environmental carcinogen 3-nitrobenzanthrone (3-NBA)found in diesel exhaust and its metabolites 3-aminobenzanthrone (3-ABA) and N-hydroxy-3-amino...

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Detalles Bibliográficos
Autores principales: Wohak, Laura E, Baranski, Ann-Christin, Krais, Annette M, Schmeiser, Heinz H, Phillips, David H, Arlt, Volker M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Manuscripts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180618/
https://www.ncbi.nlm.nih.gov/pubmed/30215795
http://dx.doi.org/10.1093/mutage/gey025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180618/
https://www.ncbi.nlm.nih.gov/pubmed/30215795
http://dx.doi.org/10.1093/mutage/gey025

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