Cargando…

The impact of p53 function on the metabolic activation of the carcinogenic air pollutant 3-nitrobenzanthrone and its metabolites 3-aminobenzanthrone and N-hydroxy-3-aminobenzanthrone in human cells

The tumour suppressor p53, encoded by TP53, is a key player in a wide network of signalling pathways. We investigated its role in the bioactivation of the environmental carcinogen 3-nitrobenzanthrone (3-NBA)found in diesel exhaust and its metabolites 3-aminobenzanthrone (3-ABA) and N-hydroxy-3-amino...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wohak, Laura E, Baranski, Ann-Christin, Krais, Annette M, Schmeiser, Heinz H, Phillips, David H, Arlt, Volker M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Original Manuscripts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180618/ https://www.ncbi.nlm.nih.gov/pubmed/30215795 http://dx.doi.org/10.1093/mutage/gey025

Ejemplares similares

Rat cytochromes P450 oxidize 3-aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone
por: Mizerovská, Jana, et al.
Publicado: (2008)

Incorporation of 3-Aminobenzanthrone into 2′-Deoxyoligonucleotides and Its Impact on Duplex Stability
por: Lukin, Mark, et al.
Publicado: (2011)

Heterocyclic Schiff Bases of 3-Aminobenzanthrone and Their Reduced Analogues: Synthesis, Properties and Spectroscopy
por: Orlova, Natalja, et al.
Publicado: (2021)

Mechanisms of Enzyme-Catalyzed Reduction of Two Carcinogenic Nitro-Aromatics, 3-Nitrobenzanthrone and Aristolochic Acid I: Experimental and Theoretical Approaches
por: Stiborová, Marie, et al.
Publicado: (2014)

TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts
por: Kucab, Jill E., et al.
Publicado: (2016)

Quantitative relationships between lacZ mutant frequency and DNA adduct frequency in Muta™Mouse tissues and cultured cells exposed to 3-nitrobenzanthrone
por: White, Paul A, et al.
Publicado: (2017)

Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone
por: Arlt, Volker M., et al.
Publicado: (2016)

Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism
por: Wohak, Laura E., et al.
Publicado: (2014)

Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles
por: Santos, Aldenor G., et al.
Publicado: (2019)

The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice
por: Krais, Annette M., et al.
Publicado: (2015)

Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts
por: Krais, Annette M., et al.
Publicado: (2015)

DNA damage in human whole blood caused by radiopharmaceuticals evaluated by the comet assay
por: Schmeiser, Heinz H, et al.
Publicado: (2019)

The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/−) and TP53(−/−) cells
por: Willis, Alexandra J., et al.
Publicado: (2018)

Synthesis and Properties of New 3-Heterylamino-Substituted 9-Nitrobenzanthrone Derivatives
por: Maļeckis, Armands, et al.
Publicado: (2023)

Effect of 2-acetylaminofluorene and its genotoxic metabolites on DNA adduct formation and DNA damage in 3D reconstructed human skin tissue models
por: Downs, Thomas R, et al.
Publicado: (2019)

Occurrence of 3-nitrobenzanthrone and other powerful mutagenic polycyclic aromatic compounds in living organisms: polychaetes
por: Sola, Maria Claudia R., et al.
Publicado: (2020)

Comparison of the oxidation of carcinogenic aristolochic acid I and II by microsomal cytochromes P450 in vitro: experimental and theoretical approaches
por: Martínek, Václav, et al.
Publicado: (2017)

Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o-anisidine and 2-nitroanisole follow from adducts generated by their metabolite N-(2-methoxyphenyl)-hydroxylamine with deoxyguanosine in DNA
por: Stiborová, Marie, et al.
Publicado: (2009)

Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene
por: Arlt, Volker M., et al.
Publicado: (2015)

Mutational Analysis of the C8-Guanine Adduct of the Environmental Carcinogen 3-Nitrobenzanthrone in Human Cells: Critical Roles of DNA Polymerases η and κ and Rev1 in Error-Prone Translesion Synthesis
por: Pande, Paritosh, et al.
Publicado: (2014)

Co-Exposure to Aristolochic Acids I and II Increases DNA Adduct Formation Responsible for Aristolochic Acid I-Mediated Carcinogenicity in Rats
por: Bárta, František, et al.
Publicado: (2021)

TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts
por: Kucab, Jill E., et al.
Publicado: (2015)

Metabolic activation of 2‐amino‐1‐methyl‐6‐phenylimidazo [4,5‐b]pyridine and DNA adduct formation depends on p53: Studies in T rp53(+/+),T rp53(+/−) and T rp53(−/−) mice
por: Krais, Annette M., et al.
Publicado: (2015)

Oxidation of the carcinogenic non-aminoazo dye 1-phenylazo-2-hydroxy-naphthalene (Sudan I) by cytochromes P450 and peroxidases: a comparative study
por: Stiborová, Marie, et al.
Publicado: (2009)

Balkan endemic nephropathy: an update on its aetiology
por: Stiborová, Marie, et al.
Publicado: (2016)

DNA Adducts Formed by Aristolochic Acid Are Unique Biomarkers of Exposure and Explain the Initiation Phase of Upper Urothelial Cancer
por: Stiborová, Marie, et al.
Publicado: (2017)

Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo
por: Dračínská, Helena, et al.
Publicado: (2016)

Nutlin‐3a selects for cells harbouring TP 53 mutations
por: Kucab, Jill E., et al.
Publicado: (2016)

Characterising Mutational Spectra of Carcinogens in the Tumour Suppressor Gene TP53 Using Human TP53 Knock-in (Hupki) Mouse Embryo Fibroblasts
por: Hölzl-Armstrong, Lisa, et al.
Publicado: (2019)

Decay of the Weyl curvature in expanding black hole cosmologies
por: Schlue, Volker
Publicado: (2022)

Error-Prone and Error-Free Translesion DNA Synthesis over Site-Specifically Created DNA Adducts of Aryl Hydrocarbons (3-Nitrobenzanthrone and 4-Aminobiphenyl)
por: Yagi, Takashi, et al.
Publicado: (2017)

Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level
por: Sasatani, Megumi, et al.
Publicado: (2017)

The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency
por: Brüsehafer, Katja, et al.
Publicado: (2016)

Cytochrome b(5) plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine
por: Stiborová, Marie, et al.
Publicado: (2017)

Measuring Thrombus Stability at High Shear, Together With Thrombus Formation and Endogenous Fibrinolysis: First Experience Using the Global Thrombosis Test 3 (GTT-3)
por: Kanji, Rahim, et al.
Publicado: (2023)

Bisphenol-A-induced inactivation of the p53 axis underlying deregulation of proliferation kinetics, and cell death in non-malignant human breast epithelial cells
por: Dairkee, Shanaz H., et al.
Publicado: (2013)

A novel in vitro 3D model of the human bone marrow to bridge the gap between in vitro and in vivo genotoxicity testing
por: Vernon, Alexander R, et al.
Publicado: (2022)

Preventing Fragility Fractures: A 3-Month Critical Window of Opportunity
por: Howenstein, Abby, et al.
Publicado: (2021)

The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo–in vitro paradox
por: Reed, Lindsay, et al.
Publicado: (2018)

Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correlation with 2D dose responses
por: Chapman, K. E., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_iginf19te5u11uc3c4fvrlqrhs