Protein deficiency reduces efficacy of oral attenuated human rotavirus vaccine in a human infant fecal microbiota transplanted gnotobiotic pig model

BACKGROUND: Low efficacy of rotavirus (RV) vaccines in developing African and Asian countries, where malnutrition is prevalent, remains a major concern and a challenge for global health. METHODS: To understand the effects of protein malnutrition on RV vaccine efficacy, we elucidated the innate, T ce...

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Detalles Bibliográficos
Autores principales: Miyazaki, Ayako, Kandasamy, Sukumar, Michael, Husheem, Langel, Stephanie N., Paim, Francine C., Chepngeno, Juliet, Alhamo, Moyasar A., Fischer, David D., Huang, Huang-Chi, Srivastava, Vishal, Kathayat, Dipak, Deblais, Loic, Rajashekara, Gireesh, Saif, Linda J., Vlasova, Anastasia N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180620/
https://www.ncbi.nlm.nih.gov/pubmed/30219368
http://dx.doi.org/10.1016/j.vaccine.2018.09.008

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