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A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson's Disease
BACKGROUND: GBA gene had been proved to be a crucial gene to the risk of PD. Numerous studies had discussed about the unique clinical characteristics of PD patients with GBA carriers (GBA + PD). However, there was lack of updated comprehensive analysis on the topic. In order to clarify the associati...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180987/ https://www.ncbi.nlm.nih.gov/pubmed/30363648 http://dx.doi.org/10.1155/2018/3136415 |
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author | Zhang, Yuan Shu, Li Zhou, Xun Pan, Hongxu Xu, Qian Guo, Jifeng Tang, Beisha Sun, Qiying |
author_facet | Zhang, Yuan Shu, Li Zhou, Xun Pan, Hongxu Xu, Qian Guo, Jifeng Tang, Beisha Sun, Qiying |
author_sort | Zhang, Yuan |
collection | PubMed |
description | BACKGROUND: GBA gene had been proved to be a crucial gene to the risk of PD. Numerous studies had discussed about the unique clinical characteristics of PD patients with GBA carriers (GBA + PD). However, there was lack of updated comprehensive analysis on the topic. In order to clarify the association between GBA variants and the clinical phenotypes of PD, we conducted this comprehensive meta-analysis. METHOD: Medline, Embase, and Cochrane were used to perform the searching. Strict selection criteria were followed in screening for new published articles or data. Revman 5.3 software was applied to perform the total statistical analysis, and funnel plots in the software were used to assess the publication biases. RESULTS: A total of 26 articles including 931 GBA + PD and 14861 GBA noncarriers of PD (GBA − PD) were involved in the final meta-analysis, and 14 of them were either newly added publications or related data newly analyzed compared with the version published in 2015. Then, a series of symptoms containing depression, orthostatic hypotension, motor fluctuation, wearing-off, and freezing were newly analyzed due to more articles eligible. Besides, clinical features like family history, AAO, UPDRS-III, H-Y, and dementia previously analyzed were updated with new data added. Significant statistical differences were found in wearing-off, family history, AAO, UPDRS-III, and dementia (OR: 1.14, 1.65; MD: −3.61, 2.17; OR: 2.44; p: 0.03, <0.00001, <0.00001, 0.003, and <0.00001). Depression was slightly associated with GBA + PD (OR: 1.47; p: 0.04). Clinical symptoms such as H-Y, orthostatic hypotension, motor fluctuation, and freezing did not feature GBA + PD. CONCLUSION: Our results demonstrated that there were unique clinical features in GBA + PD which can help the management of the whole duration of PD patients. |
format | Online Article Text |
id | pubmed-6180987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-61809872018-10-24 A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson's Disease Zhang, Yuan Shu, Li Zhou, Xun Pan, Hongxu Xu, Qian Guo, Jifeng Tang, Beisha Sun, Qiying Parkinsons Dis Review Article BACKGROUND: GBA gene had been proved to be a crucial gene to the risk of PD. Numerous studies had discussed about the unique clinical characteristics of PD patients with GBA carriers (GBA + PD). However, there was lack of updated comprehensive analysis on the topic. In order to clarify the association between GBA variants and the clinical phenotypes of PD, we conducted this comprehensive meta-analysis. METHOD: Medline, Embase, and Cochrane were used to perform the searching. Strict selection criteria were followed in screening for new published articles or data. Revman 5.3 software was applied to perform the total statistical analysis, and funnel plots in the software were used to assess the publication biases. RESULTS: A total of 26 articles including 931 GBA + PD and 14861 GBA noncarriers of PD (GBA − PD) were involved in the final meta-analysis, and 14 of them were either newly added publications or related data newly analyzed compared with the version published in 2015. Then, a series of symptoms containing depression, orthostatic hypotension, motor fluctuation, wearing-off, and freezing were newly analyzed due to more articles eligible. Besides, clinical features like family history, AAO, UPDRS-III, H-Y, and dementia previously analyzed were updated with new data added. Significant statistical differences were found in wearing-off, family history, AAO, UPDRS-III, and dementia (OR: 1.14, 1.65; MD: −3.61, 2.17; OR: 2.44; p: 0.03, <0.00001, <0.00001, 0.003, and <0.00001). Depression was slightly associated with GBA + PD (OR: 1.47; p: 0.04). Clinical symptoms such as H-Y, orthostatic hypotension, motor fluctuation, and freezing did not feature GBA + PD. CONCLUSION: Our results demonstrated that there were unique clinical features in GBA + PD which can help the management of the whole duration of PD patients. Hindawi 2018-09-27 /pmc/articles/PMC6180987/ /pubmed/30363648 http://dx.doi.org/10.1155/2018/3136415 Text en Copyright © 2018 Yuan Zhang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhang, Yuan Shu, Li Zhou, Xun Pan, Hongxu Xu, Qian Guo, Jifeng Tang, Beisha Sun, Qiying A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson's Disease |
title | A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson's Disease |
title_full | A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson's Disease |
title_fullStr | A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson's Disease |
title_full_unstemmed | A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson's Disease |
title_short | A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson's Disease |
title_sort | meta-analysis of gba-related clinical symptoms in parkinson's disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180987/ https://www.ncbi.nlm.nih.gov/pubmed/30363648 http://dx.doi.org/10.1155/2018/3136415 |
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