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A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson's Disease

BACKGROUND: GBA gene had been proved to be a crucial gene to the risk of PD. Numerous studies had discussed about the unique clinical characteristics of PD patients with GBA carriers (GBA + PD). However, there was lack of updated comprehensive analysis on the topic. In order to clarify the associati...

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Autores principales: Zhang, Yuan, Shu, Li, Zhou, Xun, Pan, Hongxu, Xu, Qian, Guo, Jifeng, Tang, Beisha, Sun, Qiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180987/
https://www.ncbi.nlm.nih.gov/pubmed/30363648
http://dx.doi.org/10.1155/2018/3136415
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author Zhang, Yuan
Shu, Li
Zhou, Xun
Pan, Hongxu
Xu, Qian
Guo, Jifeng
Tang, Beisha
Sun, Qiying
author_facet Zhang, Yuan
Shu, Li
Zhou, Xun
Pan, Hongxu
Xu, Qian
Guo, Jifeng
Tang, Beisha
Sun, Qiying
author_sort Zhang, Yuan
collection PubMed
description BACKGROUND: GBA gene had been proved to be a crucial gene to the risk of PD. Numerous studies had discussed about the unique clinical characteristics of PD patients with GBA carriers (GBA + PD). However, there was lack of updated comprehensive analysis on the topic. In order to clarify the association between GBA variants and the clinical phenotypes of PD, we conducted this comprehensive meta-analysis. METHOD: Medline, Embase, and Cochrane were used to perform the searching. Strict selection criteria were followed in screening for new published articles or data. Revman 5.3 software was applied to perform the total statistical analysis, and funnel plots in the software were used to assess the publication biases. RESULTS: A total of 26 articles including 931 GBA + PD and 14861 GBA noncarriers of PD (GBA − PD) were involved in the final meta-analysis, and 14 of them were either newly added publications or related data newly analyzed compared with the version published in 2015. Then, a series of symptoms containing depression, orthostatic hypotension, motor fluctuation, wearing-off, and freezing were newly analyzed due to more articles eligible. Besides, clinical features like family history, AAO, UPDRS-III, H-Y, and dementia previously analyzed were updated with new data added. Significant statistical differences were found in wearing-off, family history, AAO, UPDRS-III, and dementia (OR: 1.14, 1.65; MD: −3.61, 2.17; OR: 2.44; p: 0.03, <0.00001, <0.00001, 0.003, and <0.00001). Depression was slightly associated with GBA + PD (OR: 1.47; p: 0.04). Clinical symptoms such as H-Y, orthostatic hypotension, motor fluctuation, and freezing did not feature GBA + PD. CONCLUSION: Our results demonstrated that there were unique clinical features in GBA + PD which can help the management of the whole duration of PD patients.
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spelling pubmed-61809872018-10-24 A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson's Disease Zhang, Yuan Shu, Li Zhou, Xun Pan, Hongxu Xu, Qian Guo, Jifeng Tang, Beisha Sun, Qiying Parkinsons Dis Review Article BACKGROUND: GBA gene had been proved to be a crucial gene to the risk of PD. Numerous studies had discussed about the unique clinical characteristics of PD patients with GBA carriers (GBA + PD). However, there was lack of updated comprehensive analysis on the topic. In order to clarify the association between GBA variants and the clinical phenotypes of PD, we conducted this comprehensive meta-analysis. METHOD: Medline, Embase, and Cochrane were used to perform the searching. Strict selection criteria were followed in screening for new published articles or data. Revman 5.3 software was applied to perform the total statistical analysis, and funnel plots in the software were used to assess the publication biases. RESULTS: A total of 26 articles including 931 GBA + PD and 14861 GBA noncarriers of PD (GBA − PD) were involved in the final meta-analysis, and 14 of them were either newly added publications or related data newly analyzed compared with the version published in 2015. Then, a series of symptoms containing depression, orthostatic hypotension, motor fluctuation, wearing-off, and freezing were newly analyzed due to more articles eligible. Besides, clinical features like family history, AAO, UPDRS-III, H-Y, and dementia previously analyzed were updated with new data added. Significant statistical differences were found in wearing-off, family history, AAO, UPDRS-III, and dementia (OR: 1.14, 1.65; MD: −3.61, 2.17; OR: 2.44; p: 0.03, <0.00001, <0.00001, 0.003, and <0.00001). Depression was slightly associated with GBA + PD (OR: 1.47; p: 0.04). Clinical symptoms such as H-Y, orthostatic hypotension, motor fluctuation, and freezing did not feature GBA + PD. CONCLUSION: Our results demonstrated that there were unique clinical features in GBA + PD which can help the management of the whole duration of PD patients. Hindawi 2018-09-27 /pmc/articles/PMC6180987/ /pubmed/30363648 http://dx.doi.org/10.1155/2018/3136415 Text en Copyright © 2018 Yuan Zhang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhang, Yuan
Shu, Li
Zhou, Xun
Pan, Hongxu
Xu, Qian
Guo, Jifeng
Tang, Beisha
Sun, Qiying
A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson's Disease
title A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson's Disease
title_full A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson's Disease
title_fullStr A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson's Disease
title_full_unstemmed A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson's Disease
title_short A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson's Disease
title_sort meta-analysis of gba-related clinical symptoms in parkinson's disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180987/
https://www.ncbi.nlm.nih.gov/pubmed/30363648
http://dx.doi.org/10.1155/2018/3136415
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