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Antifungal and antibacterial activities of polyherbal toothpaste against oral pathogens, in vitro
BACKGROUND AND PURPOSE: Herbal toothpastes are more secure and efficacious and less poisonous due to containing natural chemicals as compared with the synthetic toothpastes. The present study aimed to formulate a polyherbal toothpaste using accessible medicinal plants in Iran and evaluate its effici...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Society of Medical Mycology
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181064/ https://www.ncbi.nlm.nih.gov/pubmed/30324153 http://dx.doi.org/10.18502/cmm.4.2.65 |
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author | Sadeghi-Nejad, Batool Moghimipour, Eskandar Yusef Naanaie, Sedigheh Nezarat, Shahrzad |
author_facet | Sadeghi-Nejad, Batool Moghimipour, Eskandar Yusef Naanaie, Sedigheh Nezarat, Shahrzad |
author_sort | Sadeghi-Nejad, Batool |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Herbal toothpastes are more secure and efficacious and less poisonous due to containing natural chemicals as compared with the synthetic toothpastes. The present study aimed to formulate a polyherbal toothpaste using accessible medicinal plants in Iran and evaluate its efficiency in the protection of oral hygiene and prevention of dental caries. MATERIALS AND METHODS: The developed toothpaste was made of the leaf extracts of Artemisia dracunculus, Satureja khuzestanica (Jamzad), and Myrtus communis (Linn), combined at four different dilutions, namely 1:4 (25%), 1:1 (50%), 3:4 (75%), and (100%), with sterile distilled water. The product was tested against five microorganisms, including Streptococcus mutans, Lactobaccilus caseie, S. sanguis, S. salivarius, and Candida albicans, using agar well diffusion method. RESULTS: After 24 h of incubation, the maximum mean diameters of inhibition zone against L. caseie and C. albicans were obtained as 17-30 and 10-25 mm, respectively. Furthermore, the minimum mean diameter of inhibition zone against S. salivarious was estimated as 15-20 mm. CONCLUSION: The formulated toothpaste showed potent inhibitory activities against Gram-positive bacteria and C. albicans. Therefore, more studies are required to accurately investigate the efficacy of the formulated toothpaste. |
format | Online Article Text |
id | pubmed-6181064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Iranian Society of Medical Mycology |
record_format | MEDLINE/PubMed |
spelling | pubmed-61810642018-10-15 Antifungal and antibacterial activities of polyherbal toothpaste against oral pathogens, in vitro Sadeghi-Nejad, Batool Moghimipour, Eskandar Yusef Naanaie, Sedigheh Nezarat, Shahrzad Curr Med Mycol Original Article BACKGROUND AND PURPOSE: Herbal toothpastes are more secure and efficacious and less poisonous due to containing natural chemicals as compared with the synthetic toothpastes. The present study aimed to formulate a polyherbal toothpaste using accessible medicinal plants in Iran and evaluate its efficiency in the protection of oral hygiene and prevention of dental caries. MATERIALS AND METHODS: The developed toothpaste was made of the leaf extracts of Artemisia dracunculus, Satureja khuzestanica (Jamzad), and Myrtus communis (Linn), combined at four different dilutions, namely 1:4 (25%), 1:1 (50%), 3:4 (75%), and (100%), with sterile distilled water. The product was tested against five microorganisms, including Streptococcus mutans, Lactobaccilus caseie, S. sanguis, S. salivarius, and Candida albicans, using agar well diffusion method. RESULTS: After 24 h of incubation, the maximum mean diameters of inhibition zone against L. caseie and C. albicans were obtained as 17-30 and 10-25 mm, respectively. Furthermore, the minimum mean diameter of inhibition zone against S. salivarious was estimated as 15-20 mm. CONCLUSION: The formulated toothpaste showed potent inhibitory activities against Gram-positive bacteria and C. albicans. Therefore, more studies are required to accurately investigate the efficacy of the formulated toothpaste. Iranian Society of Medical Mycology 2018-06 /pmc/articles/PMC6181064/ /pubmed/30324153 http://dx.doi.org/10.18502/cmm.4.2.65 Text en © 2018, Published by Mazandaran University of Medical Sciences on behalf of Iranian Society of Medical Mycology and Invasive Fungi Research Center. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Sadeghi-Nejad, Batool Moghimipour, Eskandar Yusef Naanaie, Sedigheh Nezarat, Shahrzad Antifungal and antibacterial activities of polyherbal toothpaste against oral pathogens, in vitro |
title | Antifungal and antibacterial activities of polyherbal toothpaste against oral pathogens, in vitro |
title_full | Antifungal and antibacterial activities of polyherbal toothpaste against oral pathogens, in vitro |
title_fullStr | Antifungal and antibacterial activities of polyherbal toothpaste against oral pathogens, in vitro |
title_full_unstemmed | Antifungal and antibacterial activities of polyherbal toothpaste against oral pathogens, in vitro |
title_short | Antifungal and antibacterial activities of polyherbal toothpaste against oral pathogens, in vitro |
title_sort | antifungal and antibacterial activities of polyherbal toothpaste against oral pathogens, in vitro |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181064/ https://www.ncbi.nlm.nih.gov/pubmed/30324153 http://dx.doi.org/10.18502/cmm.4.2.65 |
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