Cargando…

A single blind, multicenter, randomized controlled trial to evaluate the effectiveness and cost of a novel nutraceutical (LopiGLIK(®)) lowering cardiovascular disease risk

CONTEXT: Cardiovascular disease (CVD) costs the economy €210 billion per year in Europe. There is an association between low-density lipoprotein cholesterol (LDL-C) and CVD risk. OBJECTIVE: To evaluate the cost and effectiveness of LopiGLIK(®) (LOPI) in lowering LDL-C and CVD risk. DESIGN: Single bl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Manfrin, Andrea, Trimarco, Valentina, Manzi, Maria Virginia, Rozza, Francesco, Izzo, Raffaele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Clinical Trial Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181120/ https://www.ncbi.nlm.nih.gov/pubmed/30349338 http://dx.doi.org/10.2147/CEOR.S172838

Ejemplares similares

Effects of a New Combination of Nutraceuticals with Morus alba on Lipid Profile, Insulin Sensitivity and Endotelial Function in Dyslipidemic Subjects. A Cross-Over, Randomized, Double-Blind Trial
por: Trimarco, Valentina, et al.
Publicado: (2015)

Effects of a new combination of nutraceuticals on postmenopausal symptoms and metabolic profile: a crossover, randomized, double-blind trial
por: Trimarco, Valentina, et al.
Publicado: (2016)

Effect of a novel nutraceutical combination on serum lipoprotein functional profile and circulating PCSK9
por: Adorni, Maria Pia, et al.
Publicado: (2017)

Effects of a new nutraceutical combination on cognitive function in hypertensive patients
por: Giugliano, Giuseppe, et al.
Publicado: (2018)

Utilizing Fish Skin of Ikan Belida (Notopterus lopis) as a Source of Collagen: Production and Rheology Properties
por: Heng, Tzen T., et al.
Publicado: (2022)

Determinants of improvement of left ventricular mechano-energetic efficiency in hypertensive patients
por: Lembo, Maria, et al.
Publicado: (2022)

Different age-independent effects of nutraceutical combinations on endothelium-mediated coronary flow reserve
por: Esposito, Roberta, et al.
Publicado: (2018)

Insufficient Control of Blood Pressure and Incident Diabetes
por: Izzo, Raffaele, et al.
Publicado: (2009)

Carotid Atherosclerosis Predicts Blood Pressure Control in Patients With Hypertension: The Campania Salute Network Registry
por: Mancusi, Costantino, et al.
Publicado: (2022)

Hypertension-mediated organ damage involving multiple sites is an independent risk factor for cardiovascular events
por: Lembo, Maria, et al.
Publicado: (2023)

Combined use of amlodipine and folic acid are significantly more efficacious than amlodipine alone in lowering plasma homocysteine and blood pressure among hypertensive patients with hyperhomocysteinemia and intolerance to ACEI: A multicenter, randomized, double‐blind, parallel‐controlled clinical trial
por: Bao, Huihui, et al.
Publicado: (2023)

Therapeutic concordance improves blood pressure control in patients with resistant hypertension
por: Trimarco, Valentina, et al.
Publicado: (2023)

The therapeutic concordance approach reduces adverse drug reactions in patients with resistant hypertension
por: Trimarco, Valentina, et al.
Publicado: (2023)

New Nutraceutical Combination Reduces Blood Pressure and Improves Exercise Capacity in Hypertensive Patients Via a Nitric Oxide–Dependent Mechanism
por: Carrizzo, Albino, et al.
Publicado: (2020)

Beneficial effects of Vitamin C and L-Arginine in the treatment of post-acute sequelae of COVID-19
por: Santulli, Gaetano, et al.
Publicado: (2022)

A randomized, double-blind, active control, multicenter, dose-finding study of lipegfilgrastim (XM22) in breast cancer patients receiving myelosuppressive therapy
por: Buchner, Anton, et al.
Publicado: (2014)

Effects of adding L-arginine orally to standard therapy in patients with COVID-19: A randomized, double-blind, placebo-controlled, parallel-group trial. Results of the first interim analysis
por: Fiorentino, Giuseppe, et al.
Publicado: (2021)

Corrigendum to “Effects of adding L-arginine orally to standard therapy in patients with COVID-19: A randomized, double-blind, placebo-controlled, parallel-group trial. Results of the first interim analysis.”
por: Fiorentino, Giuseppe, et al.
Publicado: (2022)

Rizatriptan in migraineurs with unilateral cranial autonomic symptoms: a double-blind trial
por: Barbanti, Piero, et al.
Publicado: (2012)

Targeting endothelial dysfunction and oxidative stress in Long-COVID
por: Trimarco, Valentina, et al.
Publicado: (2022)

CALLA: Efficacy and safety of concurrent and adjuvant durvalumab with chemoradiotherapy versus chemoradiotherapy alone in women with locally advanced cervical cancer: a phase III, randomized, double-blind, multicenter study
por: Mayadev, Jyoti, et al.
Publicado: (2020)

Efficacy and safety of metformin plus low-dose temozolomide in patients with recurrent or refractory glioblastoma: a randomized, prospective, multicenter, double-blind, controlled, phase 2 trial (KNOG-1501 study)
por: Yoon, Wan-Soo, et al.
Publicado: (2023)

In‐hospital cost analysis of prostatic artery embolization compared with transurethral resection of the prostate: post hoc analysis of a randomized controlled trial
por: Müllhaupt, Gautier, et al.
Publicado: (2019)

The safety, effectiveness and cost‐effectiveness of cytisine in achieving six‐month continuous smoking abstinence in tuberculosis patients—protocol for a double‐blind, placebo‐controlled randomized trial
por: Dogar, Omara, et al.
Publicado: (2018)

2168: Lower rates of influenza infection following 2 dose series of high-dose vaccination in plasma cell disorders: Results of a randomized, double-blind, placebo-controlled study
por: Branagan, Andrew, et al.
Publicado: (2018)

Optimization of protocol design: a path to efficient, lower cost clinical trial execution
por: Malikova, Marina A
Publicado: (2016)

Insulin Resistance and Vitamin D Deficiency: A Link Beyond the Appearances
por: Trimarco, Valentina, et al.
Publicado: (2022)

Low mechano‐energetic efficiency is associated with future left ventricular systolic dysfunction in hypertensives
por: Manzi, Maria V., et al.
Publicado: (2022)

A randomized, multicenter, open-label, blinded end point trial comparing the effects of spironolactone to chlorthalidone on left ventricular mass in patients with early-stage chronic kidney disease: Rationale and design of the SPIRO-CKD trial
por: Hayer, Manvir K., et al.
Publicado: (2017)

Efficacy and safety of standard dose triple combination of telmisartan 80 mg/amlodipine 5 mg/chlorthalidone 25 mg in primary hypertension: A randomized, double‐blind, active‐controlled, multicenter phase 3 trial
por: Cho, Eun Joo, et al.
Publicado: (2023)

Entinostat, a class I selective histone deacetylase inhibitor, plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer: A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial
por: Xu, Binghe, et al.
Publicado: (2023)

A Multicenter, Randomized, Double-Blinded, Clinical Trial Comparing Cattell-Warren and Blumgart Anastomoses Following Partial Pancreatoduodenectomy: PANasta Trial
por: Halloran, Christopher M., et al.
Publicado: (2022)

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study of Jianyao Migu Granules in the Treatment of Osteopenic Low Back Pain
por: Qin, Zihao, et al.
Publicado: (2022)

A multicenter phase I study of preoperative chemoradiotherapy with S-1 and irinotecan for locally advanced lower rectal cancer (SAMRAI-1)
por: Sato, Takeo, et al.
Publicado: (2016)

Effect of dance on lower-limb range of motion in young people with cerebral palsy: a blinded randomized controlled clinical trial
por: Teixeira-Machado, Lavinia, et al.
Publicado: (2019)

Tenofovir disoproxil fumarate in Chinese chronic hepatitis B patients: Results of a multicenter, double-blind, double-dummy, clinical trial at 96 weeks
por: Chen, Xiao-Fan, et al.
Publicado: (2021)

Acupotomy versus Manual Acupuncture for the Treatment of Back and/or Leg Pain in Patients with Lumbar Disc Herniation: A Multicenter, Randomized, Controlled, Assessor-Blinded Clinical Trial
por: Jeong, Jeong Kyo, et al.
Publicado: (2020)

Efficacy of a nutraceutical combination on lipid metabolism in patients with metabolic syndrome: a multicenter, double blind, randomized, placebo controlled trial
por: Galletti, Ferruccio, et al.
Publicado: (2019)

Return of individual genomic research results within the PRAEGNANT multicenter registry study
por: Huebner, Hanna, et al.
Publicado: (2022)

Lipid-Lowering Nutraceuticals for an Integrative Approach to Dyslipidemia
por: Cheung, Brian, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_f4jeam8nn9k8jo6qk3loo9chae