Genomic analysis of Lassa virus from the 2018 surge in Nigeria

In early 2018 Nigeria experienced an unprecedented increase in Lassa fever cases with widespread geographic distribution. We report 77 Lassa virus genomes generated from patient samples, 14 from 2018, to investigate whether recent changes in the virus genome contributed to this surge. Our data argue...

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Autores principales: Siddle, Katherine J., Eromon, Philomena, Barnes, Kayla G., Oguzie, Judith U., Mehta, Samar, Odia, Ikponmwonsa, Shah, Rickey, Brehio, Patrick, Winnicki, Sarah M., Iruolagbe, Christopher, Aiyepada, John, Uyigue, Eghosa, Akhilomen, Patience, Okonofua, Grace, Chak, Bridget, Kotliar, Dylan, Osiemi, Blessing, Muoebonam, Ekene, Airende, Michael, Ukpetina, Rachael, Nosamiefan, Iguosadolo, Oluniyi, Paul, Ogbaini-Emovon, Ephraim, Nekouin, Mahan, Folarin, Onikepe A., Schaffner, Stephen F., Garry, Robert F., Andersen, Kristian G., Park, Daniel J., Yozwiak, Nathan L., MacInnis, Bronwyn L., Akpede, George, Okogbenin, Sylvanus, Okokhere, Peter, Sabeti, Pardis C., Happi, Christian T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Massachusetts Medical Society 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181183/
https://www.ncbi.nlm.nih.gov/pubmed/30332564
http://dx.doi.org/10.1056/NEJMoa1804498
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author Siddle, Katherine J.
Eromon, Philomena
Barnes, Kayla G.
Oguzie, Judith U.
Mehta, Samar
Odia, Ikponmwonsa
Shah, Rickey
Brehio, Patrick
Winnicki, Sarah M.
Iruolagbe, Christopher
Aiyepada, John
Uyigue, Eghosa
Akhilomen, Patience
Okonofua, Grace
Chak, Bridget
Kotliar, Dylan
Osiemi, Blessing
Muoebonam, Ekene
Airende, Michael
Ukpetina, Rachael
Nosamiefan, Iguosadolo
Oluniyi, Paul
Ogbaini-Emovon, Ephraim
Nekouin, Mahan
Folarin, Onikepe A.
Schaffner, Stephen F.
Garry, Robert F.
Andersen, Kristian G.
Park, Daniel J.
Yozwiak, Nathan L.
MacInnis, Bronwyn L.
Akpede, George
Okogbenin, Sylvanus
Okokhere, Peter
Sabeti, Pardis C.
Happi, Christian T.
author_facet Siddle, Katherine J.
Eromon, Philomena
Barnes, Kayla G.
Oguzie, Judith U.
Mehta, Samar
Odia, Ikponmwonsa
Shah, Rickey
Brehio, Patrick
Winnicki, Sarah M.
Iruolagbe, Christopher
Aiyepada, John
Uyigue, Eghosa
Akhilomen, Patience
Okonofua, Grace
Chak, Bridget
Kotliar, Dylan
Osiemi, Blessing
Muoebonam, Ekene
Airende, Michael
Ukpetina, Rachael
Nosamiefan, Iguosadolo
Oluniyi, Paul
Ogbaini-Emovon, Ephraim
Nekouin, Mahan
Folarin, Onikepe A.
Schaffner, Stephen F.
Garry, Robert F.
Andersen, Kristian G.
Park, Daniel J.
Yozwiak, Nathan L.
MacInnis, Bronwyn L.
Akpede, George
Okogbenin, Sylvanus
Okokhere, Peter
Sabeti, Pardis C.
Happi, Christian T.
author_sort Siddle, Katherine J.
collection PubMed
description In early 2018 Nigeria experienced an unprecedented increase in Lassa fever cases with widespread geographic distribution. We report 77 Lassa virus genomes generated from patient samples, 14 from 2018, to investigate whether recent changes in the virus genome contributed to this surge. Our data argue that the surge is not attributable to a single Lassa virus variant, nor has it been sustained by human-to-human transmission. We observe extensive viral diversity structured by geography, with major rivers appearing to act as barriers to migration of the rodent reservoir. Together our results support that the 2018 Lassa fever surge was driven by crossspecies transmission from local rodent populations of multiple viral variants from different lineages.
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spelling pubmed-61811832018-10-18 Genomic analysis of Lassa virus from the 2018 surge in Nigeria Siddle, Katherine J. Eromon, Philomena Barnes, Kayla G. Oguzie, Judith U. Mehta, Samar Odia, Ikponmwonsa Shah, Rickey Brehio, Patrick Winnicki, Sarah M. Iruolagbe, Christopher Aiyepada, John Uyigue, Eghosa Akhilomen, Patience Okonofua, Grace Chak, Bridget Kotliar, Dylan Osiemi, Blessing Muoebonam, Ekene Airende, Michael Ukpetina, Rachael Nosamiefan, Iguosadolo Oluniyi, Paul Ogbaini-Emovon, Ephraim Nekouin, Mahan Folarin, Onikepe A. Schaffner, Stephen F. Garry, Robert F. Andersen, Kristian G. Park, Daniel J. Yozwiak, Nathan L. MacInnis, Bronwyn L. Akpede, George Okogbenin, Sylvanus Okokhere, Peter Sabeti, Pardis C. Happi, Christian T. N Engl J Med Research Article In early 2018 Nigeria experienced an unprecedented increase in Lassa fever cases with widespread geographic distribution. We report 77 Lassa virus genomes generated from patient samples, 14 from 2018, to investigate whether recent changes in the virus genome contributed to this surge. Our data argue that the surge is not attributable to a single Lassa virus variant, nor has it been sustained by human-to-human transmission. We observe extensive viral diversity structured by geography, with major rivers appearing to act as barriers to migration of the rodent reservoir. Together our results support that the 2018 Lassa fever surge was driven by crossspecies transmission from local rodent populations of multiple viral variants from different lineages. Massachusetts Medical Society 2018-10-17 /pmc/articles/PMC6181183/ /pubmed/30332564 http://dx.doi.org/10.1056/NEJMoa1804498 Text en Copyright © 2018 Massachusetts Medical Society. https://creativecommons.org/licenses/by/4.0/ This Author Final Manuscript is licensed for use under the CC BY license.
spellingShingle Research Article
Siddle, Katherine J.
Eromon, Philomena
Barnes, Kayla G.
Oguzie, Judith U.
Mehta, Samar
Odia, Ikponmwonsa
Shah, Rickey
Brehio, Patrick
Winnicki, Sarah M.
Iruolagbe, Christopher
Aiyepada, John
Uyigue, Eghosa
Akhilomen, Patience
Okonofua, Grace
Chak, Bridget
Kotliar, Dylan
Osiemi, Blessing
Muoebonam, Ekene
Airende, Michael
Ukpetina, Rachael
Nosamiefan, Iguosadolo
Oluniyi, Paul
Ogbaini-Emovon, Ephraim
Nekouin, Mahan
Folarin, Onikepe A.
Schaffner, Stephen F.
Garry, Robert F.
Andersen, Kristian G.
Park, Daniel J.
Yozwiak, Nathan L.
MacInnis, Bronwyn L.
Akpede, George
Okogbenin, Sylvanus
Okokhere, Peter
Sabeti, Pardis C.
Happi, Christian T.
Genomic analysis of Lassa virus from the 2018 surge in Nigeria
title Genomic analysis of Lassa virus from the 2018 surge in Nigeria
title_full Genomic analysis of Lassa virus from the 2018 surge in Nigeria
title_fullStr Genomic analysis of Lassa virus from the 2018 surge in Nigeria
title_full_unstemmed Genomic analysis of Lassa virus from the 2018 surge in Nigeria
title_short Genomic analysis of Lassa virus from the 2018 surge in Nigeria
title_sort genomic analysis of lassa virus from the 2018 surge in nigeria
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181183/
https://www.ncbi.nlm.nih.gov/pubmed/30332564
http://dx.doi.org/10.1056/NEJMoa1804498
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