A Survival Case of Super-refractory Status Epilepticus due to Glutamic Acid Decarboxylase Antibodies-associated Limbic Encephalitis

Limbic encephalitis (LE) is a neurological syndrome that mainly affects mesial temporal lobes. It may present in association with cancer or infection. Limbic encephalitis associated with glutamic acid decarboxylase antibodies (anti-GAD) is rare. Here, we report a case of anti-GAD limbic encephalitis...

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Detalles Bibliográficos
Autores principales: Liu, Baoqiong, Zhou, Yan, Meng, Lingbin, Skinner, Holly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181246/
https://www.ncbi.nlm.nih.gov/pubmed/30345184
http://dx.doi.org/10.7759/cureus.3125
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author Liu, Baoqiong
Zhou, Yan
Meng, Lingbin
Skinner, Holly
author_facet Liu, Baoqiong
Zhou, Yan
Meng, Lingbin
Skinner, Holly
author_sort Liu, Baoqiong
collection PubMed
description Limbic encephalitis (LE) is a neurological syndrome that mainly affects mesial temporal lobes. It may present in association with cancer or infection. Limbic encephalitis associated with glutamic acid decarboxylase antibodies (anti-GAD) is rare. Here, we report a case of anti-GAD limbic encephalitis to heighten the awareness of this rare cause of autoimmune encephalitis. Anti-GAD-associated epilepsy is often poorly responsive to seizure medications. Treatment is challenging. Early initiation of immunotherapy is important.
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spelling pubmed-61812462018-10-19 A Survival Case of Super-refractory Status Epilepticus due to Glutamic Acid Decarboxylase Antibodies-associated Limbic Encephalitis Liu, Baoqiong Zhou, Yan Meng, Lingbin Skinner, Holly Cureus Internal Medicine Limbic encephalitis (LE) is a neurological syndrome that mainly affects mesial temporal lobes. It may present in association with cancer or infection. Limbic encephalitis associated with glutamic acid decarboxylase antibodies (anti-GAD) is rare. Here, we report a case of anti-GAD limbic encephalitis to heighten the awareness of this rare cause of autoimmune encephalitis. Anti-GAD-associated epilepsy is often poorly responsive to seizure medications. Treatment is challenging. Early initiation of immunotherapy is important. Cureus 2018-08-10 /pmc/articles/PMC6181246/ /pubmed/30345184 http://dx.doi.org/10.7759/cureus.3125 Text en Copyright © 2018, Liu et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Liu, Baoqiong
Zhou, Yan
Meng, Lingbin
Skinner, Holly
A Survival Case of Super-refractory Status Epilepticus due to Glutamic Acid Decarboxylase Antibodies-associated Limbic Encephalitis
title A Survival Case of Super-refractory Status Epilepticus due to Glutamic Acid Decarboxylase Antibodies-associated Limbic Encephalitis
title_full A Survival Case of Super-refractory Status Epilepticus due to Glutamic Acid Decarboxylase Antibodies-associated Limbic Encephalitis
title_fullStr A Survival Case of Super-refractory Status Epilepticus due to Glutamic Acid Decarboxylase Antibodies-associated Limbic Encephalitis
title_full_unstemmed A Survival Case of Super-refractory Status Epilepticus due to Glutamic Acid Decarboxylase Antibodies-associated Limbic Encephalitis
title_short A Survival Case of Super-refractory Status Epilepticus due to Glutamic Acid Decarboxylase Antibodies-associated Limbic Encephalitis
title_sort survival case of super-refractory status epilepticus due to glutamic acid decarboxylase antibodies-associated limbic encephalitis
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181246/
https://www.ncbi.nlm.nih.gov/pubmed/30345184
http://dx.doi.org/10.7759/cureus.3125
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