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Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance: Evidence Against a Hyperkinetic State

Unlike in older people, it has been suggested that elevated blood pressure (BP) in young people is because of high cardiac output accompanied by normal total peripheral resistance (TPR)—a hyperkinetic/hyperdynamic circulation. We investigated this in a large, United Kingdom-based birth cohort of ado...

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Autores principales: Park, Chloe, Fraser, Abigail, Howe, Laura D., Jones, Siana, Davey Smith, George, Lawlor, Debbie A., Chaturvedi, Nish, Hughes, Alun D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott, Williams & Wilkins 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181289/
https://www.ncbi.nlm.nih.gov/pubmed/30354820
http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11925
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author Park, Chloe
Fraser, Abigail
Howe, Laura D.
Jones, Siana
Davey Smith, George
Lawlor, Debbie A.
Chaturvedi, Nish
Hughes, Alun D.
author_facet Park, Chloe
Fraser, Abigail
Howe, Laura D.
Jones, Siana
Davey Smith, George
Lawlor, Debbie A.
Chaturvedi, Nish
Hughes, Alun D.
author_sort Park, Chloe
collection PubMed
description Unlike in older people, it has been suggested that elevated blood pressure (BP) in young people is because of high cardiac output accompanied by normal total peripheral resistance (TPR)—a hyperkinetic/hyperdynamic circulation. We investigated this in a large, United Kingdom-based birth cohort of adolescents. The study was conducted on 2091 17-year-old participants in the ALSPAC (Avon Longitudinal Study of Parents and Children)—a prospective population-based birth cohort study. BP measurement and echocardiography were performed, and heart rate (HR), stroke volume (SV), and TPR were calculated. Data are means (SD). Higher quintiles of systolic BP were associated with higher SV, higher HR, and higher TPR. The proportional contribution made by SV, HR, and TPR to mean arterial pressure differed little by systolic BP quintile (SV [32%–34%], HR [25%–29%], and TPR [39%–41%]). Higher BP is attributable to a combination of higher cardiac output (ie, SV×HR) and higher TPR in a population-based sample of adolescents. There is no evidence of a disproportionate contribution from elevated cardiac output at higher BP levels.
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spelling pubmed-61812892018-10-25 Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance: Evidence Against a Hyperkinetic State Park, Chloe Fraser, Abigail Howe, Laura D. Jones, Siana Davey Smith, George Lawlor, Debbie A. Chaturvedi, Nish Hughes, Alun D. Hypertension Original Articles Unlike in older people, it has been suggested that elevated blood pressure (BP) in young people is because of high cardiac output accompanied by normal total peripheral resistance (TPR)—a hyperkinetic/hyperdynamic circulation. We investigated this in a large, United Kingdom-based birth cohort of adolescents. The study was conducted on 2091 17-year-old participants in the ALSPAC (Avon Longitudinal Study of Parents and Children)—a prospective population-based birth cohort study. BP measurement and echocardiography were performed, and heart rate (HR), stroke volume (SV), and TPR were calculated. Data are means (SD). Higher quintiles of systolic BP were associated with higher SV, higher HR, and higher TPR. The proportional contribution made by SV, HR, and TPR to mean arterial pressure differed little by systolic BP quintile (SV [32%–34%], HR [25%–29%], and TPR [39%–41%]). Higher BP is attributable to a combination of higher cardiac output (ie, SV×HR) and higher TPR in a population-based sample of adolescents. There is no evidence of a disproportionate contribution from elevated cardiac output at higher BP levels. Lippincott, Williams & Wilkins 2018-11 2018-10-01 /pmc/articles/PMC6181289/ /pubmed/30354820 http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11925 Text en © 2018 The Authors. Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.
spellingShingle Original Articles
Park, Chloe
Fraser, Abigail
Howe, Laura D.
Jones, Siana
Davey Smith, George
Lawlor, Debbie A.
Chaturvedi, Nish
Hughes, Alun D.
Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance: Evidence Against a Hyperkinetic State
title Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance: Evidence Against a Hyperkinetic State
title_full Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance: Evidence Against a Hyperkinetic State
title_fullStr Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance: Evidence Against a Hyperkinetic State
title_full_unstemmed Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance: Evidence Against a Hyperkinetic State
title_short Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance: Evidence Against a Hyperkinetic State
title_sort elevated blood pressure in adolescence is attributable to a combination of elevated cardiac output and total peripheral resistance: evidence against a hyperkinetic state
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181289/
https://www.ncbi.nlm.nih.gov/pubmed/30354820
http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11925
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