The arginase inhibitor N(ω)−hydroxy−nor−arginine (nor−NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target

Cancer cells, including in chronic myeloid leukemia (CML), depend on the hypoxic response to persist in hosts and evade therapy. Accordingly, there is significant interest in drugging cancer-specific hypoxic responses. However, a major challenge in leukemia is identifying differential and druggable...

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Detalles Bibliográficos
Autores principales: Ng, King Pan, Manjeri, Aditi, Lee, Lin Ming, Chan, Zhu En, Tan, Chin Yee, Tan, Qiancheng Darren, Majeed, A'Qilah, Lee, Kian Leong, Chuah, Charles, Suda, Toshio, Ong, S. Tiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181325/
https://www.ncbi.nlm.nih.gov/pubmed/30307989
http://dx.doi.org/10.1371/journal.pone.0205254

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