Cargando…

ALDH1A1 expression is associated with poor differentiation, ‘right-sidedness’ and poor survival in human colorectal cancer

BACKGROUND: Aldehyde dehydrogenase 1A1 (ALDH1A1) encodes an enzyme that oxidizes aldehydes to their corresponding carboxylic acids. In colorectal cancer ALDH1A1 marks cancer stem cells and plays putative roles in tumor progression and drug resistance. However, the potential value of ALDH1A1 as a dia...

Descripción completa

Detalles Bibliográficos
Autores principales:	van der Waals, Lizet M., Borel Rinkes, Inne H. M., Kranenburg, Onno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181398/ https://www.ncbi.nlm.nih.gov/pubmed/30308036 http://dx.doi.org/10.1371/journal.pone.0205536

Ejemplares similares

Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures
por: van der Waals, Lizet M., et al.
Publicado: (2019)

Differential Notch and TGFβ Signaling in Primary Colorectal Tumors and Their Corresponding Metastases
por: Veenendaal, Liesbeth M., et al.
Publicado: (2008)

Downregulation of DNA repair proteins and increased DNA damage in hypoxic colon cancer cells is a therapeutically exploitable vulnerability
por: Jongen, Jennifer M. J., et al.
Publicado: (2017)

Detection of Experimental Colorectal Peritoneal Metastases by a Novel PDGFRβ-Targeting Nanobody
por: Strating, Esther, et al.
Publicado: (2022)

Paired image- and FACS-based toxicity assays for high content screening of spheroid-type tumor cell cultures
por: Trumpi, Kari, et al.
Publicado: (2015)

Loss of Neuropilin-2 in Murine Mesenchymal-like Colon Cancer Organoids Causes Mesenchymal-to-Epithelial Transition and an Acquired Dependency on Insulin-Receptor Signaling and Autophagy
por: Poghosyan, Susanna, et al.
Publicado: (2022)

Invited Commentary: Overall Survival in Patients with Stage IV Pan-NET Eligible for Liver Transplantation
por: Borel Rinkes, Inne H. M.
Publicado: (2022)

Oncogenic K-Ras Activates p38 to Maintain Colorectal Cancer Cell Proliferation during MEK Inhibition
por: van Houdt, Winan J., et al.
Publicado: (2010)

High ALDH1A1 expression correlates with poor survival in papillary thyroid carcinoma
por: Xing, Yue, et al.
Publicado: (2014)

ALDH1B1 predicts poor survival for locally advanced nasopharyngeal carcinoma patients
por: Zhu, Tao, et al.
Publicado: (2022)

Liver lymphatic drainage patterns follow segmental anatomy in a murine model
por: Frenkel, Nicola C., et al.
Publicado: (2020)

Mode of progression after radioembolization in patients with colorectal cancer liver metastases
por: van Roekel, Caren, et al.
Publicado: (2020)

“Sidedness” as a standard hypernym for “right” and “left” in anatomy
por: Amarin, Justin Z., et al.
Publicado: (2021)

Impact of sidedness of colorectal cancer on tumor immunity
por: Takasu, Chie, et al.
Publicado: (2020)

Colon Cancer Sidedness, Presentation, and Survival at Different Stages
por: Ulanja, Mark B., et al.
Publicado: (2019)

Liver lymphatic drainage patterns follow segmental anatomy
por: van den Bent, Lotte, et al.
Publicado: (2022)

CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer
por: Pennel, Kathryn AF, et al.
Publicado: (2022)

Tissue clearing and immunostaining to visualize the spatial organization of vasculature and tumor cells in mouse liver
por: Frenkel, Nicola, et al.
Publicado: (2023)

Expression of HIF-1α in medullary thyroid cancer identifies a subgroup with poor prognosis
por: Lodewijk, Lutske, et al.
Publicado: (2017)

Tim3 and PD-1 as a therapeutic and prognostic targets in colorectal cancer: Relationship with sidedness, clinicopathological parameters, and survival
por: Mokhtari, Zahra, et al.
Publicado: (2023)

Low expression of aldehyde deyhdrogenase 1A1 (ALDH1A1) is a prognostic marker for poor survival in pancreatic cancer
por: Kahlert, Christoph, et al.
Publicado: (2011)

CD95 ligand induces senescence in mismatch repair-deficient human colon cancer via chronic caspase-mediated induction of DNA damage
por: Raats, Danielle A, et al.
Publicado: (2017)

Correlation between c-Met and ALDH1 contributes to the survival and tumor-sphere formation of ALDH1 positive breast cancer stem cells and predicts poor clinical outcome in breast cancer
por: Nozaki, Yuka, et al.
Publicado: (2017)

The combination of aldehyde dehydrogenase 1 (ALDH1) and CD44 is associated with poor outcomes in endometrial cancer
por: Huang, Hsin-Hui, et al.
Publicado: (2018)

Modeling resistance of colorectal peritoneal metastases to immune checkpoint blockade in humanized mice
por: Küçükköse, Emre, et al.
Publicado: (2022)

Upregulated NLGN1 predicts poor survival in colorectal cancer
por: Yu, Qian, et al.
Publicado: (2021)

Sidedness determines clinical characteristics and survival outcomes in medullary adenocarcinoma of the colon
por: Blakely, Andrew M., et al.
Publicado: (2021)

ITGA7, CD133, ALDH1 are inter‐correlated, and linked with poor differentiation, lymph node metastasis as well as worse survival in surgical cervical cancer
por: Yuan, Na, et al.
Publicado: (2022)

Predicting early extrahepatic recurrence after local treatment of colorectal liver metastases
por: Wensink, G E, et al.
Publicado: (2023)

Loss of Villin Immunoexpression in Colorectal Carcinoma Is Associated with Poor Differentiation and Survival
por: Al-Maghrabi, Jaudah, et al.
Publicado: (2013)

Impact of tumor sidedness on survival and recurrence patterns in colon cancer patients
por: Lee, Jong Min, et al.
Publicado: (2019)

CK1α overexpression correlates with poor survival in colorectal cancer
por: Richter, Julia, et al.
Publicado: (2018)

Primary Tumor Sidedness Predicts Bevacizumab Benefit in Metastatic Colorectal Cancer Patients
por: You, Xia-Hong, et al.
Publicado: (2019)

The Impact of Primary Tumor Sidedness on the Effect of Regorafenib in Refractory Metastatic Colorectal Cancer
por: Yoon, Sang Eun, et al.
Publicado: (2019)

Neuroendocrine differentiation is predictive of poor survival in patients with stage II colorectal cancer
por: Liu, Yue, et al.
Publicado: (2017)

Positive ALDH1A3 and Negative GPX3 Expressions Are Biomarkers for Poor Prognosis of Gallbladder Cancer
por: Yang, Zhu-lin, et al.
Publicado: (2013)

ALDH1-High Ovarian Cancer Stem-Like Cells Can Be Isolated from Serous and Clear Cell Adenocarcinoma Cells, and ALDH1 High Expression Is Associated with Poor Prognosis
por: Kuroda, Takafumi, et al.
Publicado: (2013)

Bevacizumab in metastatic colorectal cancer in a real-life setting – toxicity profile, survival outcomes, and impact of tumor sidedness
por: Chibani, Hind, et al.
Publicado: (2022)

Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival
por: Herath, N I, et al.
Publicado: (2009)

Co-expression of cancer stem cell markers, SALL4/ALDH1A1, is associated with tumor aggressiveness and poor survival in patients with serous ovarian carcinoma
por: Sharbatoghli, Mina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_tblecc1e603nibm3pf97cp4342