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Use of an individual-based model of pneumococcal carriage for planning a randomized trial of a whole-cell vaccine
For encapsulated bacteria such as Streptococcus pneumoniae, asymptomatic carriage is more common and longer in duration than disease, and hence is often a more convenient endpoint for clinical trials of vaccines against these bacteria. However, using a carriage endpoint entails specific challenges....
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181404/ https://www.ncbi.nlm.nih.gov/pubmed/30273332 http://dx.doi.org/10.1371/journal.pcbi.1006333 |