A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity

Antibodies to the prion protein, PrP, represent a promising therapeutic approach against prion diseases but the neurotoxicity of certain anti-PrP antibodies has caused concern. Here we describe scPOM-bi, a bispecific antibody designed to function as a molecular prion tweezer. scPOM-bi combines the c...

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Detalles Bibliográficos
Autores principales: Bardelli, Marco, Frontzek, Karl, Simonelli, Luca, Hornemann, Simone, Pedotti, Mattia, Mazzola, Federica, Carta, Manfredi, Eckhardt, Valeria, D’Antuono, Rocco, Virgilio, Tommaso, González, Santiago F., Aguzzi, Adriano, Varani, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181439/
https://www.ncbi.nlm.nih.gov/pubmed/30273408
http://dx.doi.org/10.1371/journal.ppat.1007335

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