A Destabilizing Domain Allows for Fast, Noninvasive, Conditional Control of Protein Abundance in the Mouse Eye – Implications for Ocular Gene Therapy

PURPOSE: Temporal and reversible control of protein expression in vivo is a central goal for many gene therapies, especially for strategies involving proteins that are detrimental to physiology if constitutively expressed. Accordingly, we explored whether protein abundance in the mouse retina could...

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Detalles Bibliográficos
Autores principales: Datta, Shyamtanu, Renwick, Marian, Chau, Viet Q., Zhang, Fang, Nettesheim, Emily R., Lipinski, Daniel M., Hulleman, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2018
Materias:
Retina
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181441/
https://www.ncbi.nlm.nih.gov/pubmed/30347085
http://dx.doi.org/10.1167/iovs.18-24987

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