Cargando…

Role of Ginkgo biloba extract as an adjunctive treatment of elderly patients with depression and on the expression of serum S100B

OBJECTIVE: To explore the effect of ginkgo biloba extract (EGb) as an adjunctive treatment of elderly patients with depression and the effect on the expression of serum S100B. METHODS: 136 elderly patients with depression were divided into EGb +  citalopram (Cit) group and Cit group equally. Efficac...

Descripción completa

Detalles Bibliográficos
Autores principales: Dai, Chun-Xiao, Hu, Chang-Chun, Shang, Yu-Shan, Xie, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181482/
https://www.ncbi.nlm.nih.gov/pubmed/30278520
http://dx.doi.org/10.1097/MD.0000000000012421
_version_ 1783362408296742912
author Dai, Chun-Xiao
Hu, Chang-Chun
Shang, Yu-Shan
Xie, Jian
author_facet Dai, Chun-Xiao
Hu, Chang-Chun
Shang, Yu-Shan
Xie, Jian
author_sort Dai, Chun-Xiao
collection PubMed
description OBJECTIVE: To explore the effect of ginkgo biloba extract (EGb) as an adjunctive treatment of elderly patients with depression and the effect on the expression of serum S100B. METHODS: 136 elderly patients with depression were divided into EGb +  citalopram (Cit) group and Cit group equally. Efficacy was evaluated by Hamilton Depression Rating Scale (HAMD). Wisconsin Card Classification Test (WCST) was used to evaluate cognitive function. Serum S100B expression was measured with ELISA. The relationship of S100B with HAMD, Hamilton Anxiety Scale (HAMA) score, and WCST results was evaluated subsequently. RESULTS: The time of onset of efficacy was significantly shorter in EGb + Cit group. There were significant differences in HAMD and HAMA scores after treatment than before treatment between groups (all P < .05). After treatment, total number of WCST test, the number of continuous errors and non-persistent errors in both groups were less than those before treatment. The correct number and classifications number were increased than before treatment. In EGb + Cit group, correct numbers and classifications were increased, and the number of persistent errors was decreased. After treatment, S100B level was decreased, and S100B levels change in EGb + Cit group was greater than in Cit group. Serum S100B level was positively correlated with HAMD and HAMA scores before treatment and positively correlated with persistent errors number in WCST. CONCLUSION: EGb, as an adjunctive treatment, can effectively improve depressive symptoms and reduce expression of serum S100B, which is a marker of brain injury, suggesting that EGb restores neurologic function during the treatment of depression in elderly patients and S100B participates in the therapeutic mechanism. EGb combined with depressive drugs plays synergistic role, and the time of onset of efficacy is faster than single antidepressants.
format Online
Article
Text
id pubmed-6181482
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-61814822018-10-15 Role of Ginkgo biloba extract as an adjunctive treatment of elderly patients with depression and on the expression of serum S100B Dai, Chun-Xiao Hu, Chang-Chun Shang, Yu-Shan Xie, Jian Medicine (Baltimore) Research Article OBJECTIVE: To explore the effect of ginkgo biloba extract (EGb) as an adjunctive treatment of elderly patients with depression and the effect on the expression of serum S100B. METHODS: 136 elderly patients with depression were divided into EGb +  citalopram (Cit) group and Cit group equally. Efficacy was evaluated by Hamilton Depression Rating Scale (HAMD). Wisconsin Card Classification Test (WCST) was used to evaluate cognitive function. Serum S100B expression was measured with ELISA. The relationship of S100B with HAMD, Hamilton Anxiety Scale (HAMA) score, and WCST results was evaluated subsequently. RESULTS: The time of onset of efficacy was significantly shorter in EGb + Cit group. There were significant differences in HAMD and HAMA scores after treatment than before treatment between groups (all P < .05). After treatment, total number of WCST test, the number of continuous errors and non-persistent errors in both groups were less than those before treatment. The correct number and classifications number were increased than before treatment. In EGb + Cit group, correct numbers and classifications were increased, and the number of persistent errors was decreased. After treatment, S100B level was decreased, and S100B levels change in EGb + Cit group was greater than in Cit group. Serum S100B level was positively correlated with HAMD and HAMA scores before treatment and positively correlated with persistent errors number in WCST. CONCLUSION: EGb, as an adjunctive treatment, can effectively improve depressive symptoms and reduce expression of serum S100B, which is a marker of brain injury, suggesting that EGb restores neurologic function during the treatment of depression in elderly patients and S100B participates in the therapeutic mechanism. EGb combined with depressive drugs plays synergistic role, and the time of onset of efficacy is faster than single antidepressants. Wolters Kluwer Health 2018-09-28 /pmc/articles/PMC6181482/ /pubmed/30278520 http://dx.doi.org/10.1097/MD.0000000000012421 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle Research Article
Dai, Chun-Xiao
Hu, Chang-Chun
Shang, Yu-Shan
Xie, Jian
Role of Ginkgo biloba extract as an adjunctive treatment of elderly patients with depression and on the expression of serum S100B
title Role of Ginkgo biloba extract as an adjunctive treatment of elderly patients with depression and on the expression of serum S100B
title_full Role of Ginkgo biloba extract as an adjunctive treatment of elderly patients with depression and on the expression of serum S100B
title_fullStr Role of Ginkgo biloba extract as an adjunctive treatment of elderly patients with depression and on the expression of serum S100B
title_full_unstemmed Role of Ginkgo biloba extract as an adjunctive treatment of elderly patients with depression and on the expression of serum S100B
title_short Role of Ginkgo biloba extract as an adjunctive treatment of elderly patients with depression and on the expression of serum S100B
title_sort role of ginkgo biloba extract as an adjunctive treatment of elderly patients with depression and on the expression of serum s100b
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181482/
https://www.ncbi.nlm.nih.gov/pubmed/30278520
http://dx.doi.org/10.1097/MD.0000000000012421
work_keys_str_mv AT daichunxiao roleofginkgobilobaextractasanadjunctivetreatmentofelderlypatientswithdepressionandontheexpressionofserums100b
AT huchangchun roleofginkgobilobaextractasanadjunctivetreatmentofelderlypatientswithdepressionandontheexpressionofserums100b
AT shangyushan roleofginkgobilobaextractasanadjunctivetreatmentofelderlypatientswithdepressionandontheexpressionofserums100b
AT xiejian roleofginkgobilobaextractasanadjunctivetreatmentofelderlypatientswithdepressionandontheexpressionofserums100b