ANRIL polymorphism rs4977574 is associated with increased risk of coronary artery disease in Asian populations: A meta-analysis of 12,005 subjects

BACKGROUND: Several studies have shown that ANRIL polymorphism may be associated with the risk of coronary artery disease (CAD). However, these studies do not provide a clear consensus in Asian population. Thus, this meta-analysis was aimed to evaluate the relationship between the common variant rs4977574 in ANRIL and CAD risk in Asian population. METHODS: We conducted a systematic literature search of PubMed, Embase and the Cochrane Library and 2 Chinese databases. A total of 12,005 subjects from 6 independent studies were included. The pooled odds ratio (OR) and their corresponding 95% confidence intervals (CIs) were used to assess the association between rs4977574 and CAD using random effects model. RESULTS: A significant association was observed between rs4977574 and CAD risk under the allelic (OR: 1.18, 95% CI: 1.04–1.34, P = .010), recessive (OR: 1.27, 95% CI: 1.01–1.60, P = .04), dominant (OR: 1.28, 95% CI: 1.13–1.44, P = .002), homozygous (OR: 1.46, 95% CI: 1.15–1.86, P = .002), and heterozygous model (OR: 1.17, 95% CI: 1.07–1.28, P = .0004), especially in the Chinese subgroup and the myocardial infarction (MI) subgroup (P < .05). CONCLUSION: The ANRIL polymorphism rs4977574 is associated with CAD risk in Asian population. The rs4977574 with G allele may confer to a higher risk of CAD, especially MI.