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A complex peripheral code for salt taste in Drosophila
Each taste modality is generally encoded by a single, molecularly defined, population of sensory cells. However, salt stimulates multiple taste pathways in mammals and insects, suggesting a more complex code for salt taste. Here, we examine salt coding in Drosophila. After creating a comprehensive m...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181562/ https://www.ncbi.nlm.nih.gov/pubmed/30307393 http://dx.doi.org/10.7554/eLife.37167 |
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author | Jaeger, Alexandria H Stanley, Molly Weiss, Zachary F Musso, Pierre-Yves Chan, Rachel CW Zhang, Han Feldman-Kiss, Damian Gordon, Michael D |
author_facet | Jaeger, Alexandria H Stanley, Molly Weiss, Zachary F Musso, Pierre-Yves Chan, Rachel CW Zhang, Han Feldman-Kiss, Damian Gordon, Michael D |
author_sort | Jaeger, Alexandria H |
collection | PubMed |
description | Each taste modality is generally encoded by a single, molecularly defined, population of sensory cells. However, salt stimulates multiple taste pathways in mammals and insects, suggesting a more complex code for salt taste. Here, we examine salt coding in Drosophila. After creating a comprehensive molecular map comprised of five discrete sensory neuron classes across the fly labellum, we find that four are activated by salt: two exhibiting characteristics of ‘low salt’ cells, and two ‘high salt’ classes. Behaviorally, low salt attraction depends primarily on ‘sweet’ neurons, with additional input from neurons expressing the ionotropic receptor IR94e. High salt avoidance is mediated by ‘bitter’ neurons and a population of glutamatergic neurons expressing Ppk23. Interestingly, the impact of these glutamatergic neurons depends on prior salt consumption. These results support a complex model for salt coding in flies that combinatorially integrates inputs from across cell types to afford robust and flexible salt behaviors. |
format | Online Article Text |
id | pubmed-6181562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-61815622018-10-18 A complex peripheral code for salt taste in Drosophila Jaeger, Alexandria H Stanley, Molly Weiss, Zachary F Musso, Pierre-Yves Chan, Rachel CW Zhang, Han Feldman-Kiss, Damian Gordon, Michael D eLife Neuroscience Each taste modality is generally encoded by a single, molecularly defined, population of sensory cells. However, salt stimulates multiple taste pathways in mammals and insects, suggesting a more complex code for salt taste. Here, we examine salt coding in Drosophila. After creating a comprehensive molecular map comprised of five discrete sensory neuron classes across the fly labellum, we find that four are activated by salt: two exhibiting characteristics of ‘low salt’ cells, and two ‘high salt’ classes. Behaviorally, low salt attraction depends primarily on ‘sweet’ neurons, with additional input from neurons expressing the ionotropic receptor IR94e. High salt avoidance is mediated by ‘bitter’ neurons and a population of glutamatergic neurons expressing Ppk23. Interestingly, the impact of these glutamatergic neurons depends on prior salt consumption. These results support a complex model for salt coding in flies that combinatorially integrates inputs from across cell types to afford robust and flexible salt behaviors. eLife Sciences Publications, Ltd 2018-10-11 /pmc/articles/PMC6181562/ /pubmed/30307393 http://dx.doi.org/10.7554/eLife.37167 Text en © 2018, Jaeger et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Jaeger, Alexandria H Stanley, Molly Weiss, Zachary F Musso, Pierre-Yves Chan, Rachel CW Zhang, Han Feldman-Kiss, Damian Gordon, Michael D A complex peripheral code for salt taste in Drosophila |
title | A complex peripheral code for salt taste in Drosophila |
title_full | A complex peripheral code for salt taste in Drosophila |
title_fullStr | A complex peripheral code for salt taste in Drosophila |
title_full_unstemmed | A complex peripheral code for salt taste in Drosophila |
title_short | A complex peripheral code for salt taste in Drosophila |
title_sort | complex peripheral code for salt taste in drosophila |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181562/ https://www.ncbi.nlm.nih.gov/pubmed/30307393 http://dx.doi.org/10.7554/eLife.37167 |
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