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The elevated prevalence of risk factors for chronic liver disease among ageing people with hemophilia and implications for treatment

Chronic liver disease (CLD) is frequently seen in the hemophilia population. The ADVANCE Working Group conducted a cross-sectional study in which people with hemophilia (PWH) aged ≥40 years were included. This study aimed to assess the associations between CLD and its risk factors using data from th...

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Autores principales: Qvigstad, Christian, Tait, Robert Campbell, Rauchensteiner, Stephan, Berntorp, Erik, de Moerloose, Philippe, Schutgens, Roger E., Holme, Pål Andre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181599/
https://www.ncbi.nlm.nih.gov/pubmed/30278553
http://dx.doi.org/10.1097/MD.0000000000012551
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author Qvigstad, Christian
Tait, Robert Campbell
Rauchensteiner, Stephan
Berntorp, Erik
de Moerloose, Philippe
Schutgens, Roger E.
Holme, Pål Andre
author_facet Qvigstad, Christian
Tait, Robert Campbell
Rauchensteiner, Stephan
Berntorp, Erik
de Moerloose, Philippe
Schutgens, Roger E.
Holme, Pål Andre
author_sort Qvigstad, Christian
collection PubMed
description Chronic liver disease (CLD) is frequently seen in the hemophilia population. The ADVANCE Working Group conducted a cross-sectional study in which people with hemophilia (PWH) aged ≥40 years were included. This study aimed to assess the associations between CLD and its risk factors using data from the H3 study, and to suggest implications for optimal care. Data from 13 European countries were collected at a single time-point (2011–2013). Univariate and multivariate logistic regression (MLR) analyses were performed. A total of 532 PWH were included with either hemophilia A (n = 467) or hemophilia B (n = 65). A total of 127 (24%) were diagnosed with CLD. Hepatitis C virus (HCV), human immunodeficiency virus (HIV), total cholesterol, and severe hemophilia were significant risk factors in univariate logistic regressions. In MLR, HCV Ab+/PCR+ (OR = 17.6, P < .001), diabetes (OR = 3.0, P = .02), and HIV (OR = 1.9, P = .049) were positively associated with CLD. Total cholesterol (OR = 0.6, P = .002) was negatively associated with CLD. We found no evidence of interaction effects among the explanatory variables. No significant associations with age and type of or severity of hemophilia were observed in MLR. The main risk factors for CLD in this European cohort also apply to the general population, but the prevalence of HCV and HIV is considerably larger in this cohort. With new and improved treatment options, intensified eradication therapy for HCV seems justified to prevent CLD. Similarly, intensified monitoring and treatment of diabetes seem warranted.
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spelling pubmed-61815992018-10-15 The elevated prevalence of risk factors for chronic liver disease among ageing people with hemophilia and implications for treatment Qvigstad, Christian Tait, Robert Campbell Rauchensteiner, Stephan Berntorp, Erik de Moerloose, Philippe Schutgens, Roger E. Holme, Pål Andre Medicine (Baltimore) Research Article Chronic liver disease (CLD) is frequently seen in the hemophilia population. The ADVANCE Working Group conducted a cross-sectional study in which people with hemophilia (PWH) aged ≥40 years were included. This study aimed to assess the associations between CLD and its risk factors using data from the H3 study, and to suggest implications for optimal care. Data from 13 European countries were collected at a single time-point (2011–2013). Univariate and multivariate logistic regression (MLR) analyses were performed. A total of 532 PWH were included with either hemophilia A (n = 467) or hemophilia B (n = 65). A total of 127 (24%) were diagnosed with CLD. Hepatitis C virus (HCV), human immunodeficiency virus (HIV), total cholesterol, and severe hemophilia were significant risk factors in univariate logistic regressions. In MLR, HCV Ab+/PCR+ (OR = 17.6, P < .001), diabetes (OR = 3.0, P = .02), and HIV (OR = 1.9, P = .049) were positively associated with CLD. Total cholesterol (OR = 0.6, P = .002) was negatively associated with CLD. We found no evidence of interaction effects among the explanatory variables. No significant associations with age and type of or severity of hemophilia were observed in MLR. The main risk factors for CLD in this European cohort also apply to the general population, but the prevalence of HCV and HIV is considerably larger in this cohort. With new and improved treatment options, intensified eradication therapy for HCV seems justified to prevent CLD. Similarly, intensified monitoring and treatment of diabetes seem warranted. Wolters Kluwer Health 2018-09-28 /pmc/articles/PMC6181599/ /pubmed/30278553 http://dx.doi.org/10.1097/MD.0000000000012551 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Qvigstad, Christian
Tait, Robert Campbell
Rauchensteiner, Stephan
Berntorp, Erik
de Moerloose, Philippe
Schutgens, Roger E.
Holme, Pål Andre
The elevated prevalence of risk factors for chronic liver disease among ageing people with hemophilia and implications for treatment
title The elevated prevalence of risk factors for chronic liver disease among ageing people with hemophilia and implications for treatment
title_full The elevated prevalence of risk factors for chronic liver disease among ageing people with hemophilia and implications for treatment
title_fullStr The elevated prevalence of risk factors for chronic liver disease among ageing people with hemophilia and implications for treatment
title_full_unstemmed The elevated prevalence of risk factors for chronic liver disease among ageing people with hemophilia and implications for treatment
title_short The elevated prevalence of risk factors for chronic liver disease among ageing people with hemophilia and implications for treatment
title_sort elevated prevalence of risk factors for chronic liver disease among ageing people with hemophilia and implications for treatment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181599/
https://www.ncbi.nlm.nih.gov/pubmed/30278553
http://dx.doi.org/10.1097/MD.0000000000012551
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