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Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo

The stereotypical distribution of TAR DNA-binding 43 protein (TDP-43) aggregates in frontotemporal lobar degeneration (FTLD-TDP) suggests that pathological TDP-43 spreads throughout the brain via cell-to-cell transmission and correlates with disease progression, but no in vivo experimental data supp...

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Detalles Bibliográficos
Autores principales:	Porta, Sílvia, Xu, Yan, Restrepo, Clark R., Kwong, Linda K., Zhang, Bin, Brown, Hannah J., Lee, Edward B., Trojanowski, John Q., Lee, Virginia M.-Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181940/ https://www.ncbi.nlm.nih.gov/pubmed/30310141 http://dx.doi.org/10.1038/s41467-018-06548-9

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