Cargando…

Development of a Stable MGAT1(−) CHO Cell Line to Produce Clade C gp120 With Improved Binding to Broadly Neutralizing Antibodies

The high rate of new HIV infections, particularly in Sub-Saharan Africa, emphasizes the need for a safe and effective vaccine to prevent acquired immunodeficiency syndrome (AIDS). To date, the only HIV vaccine trial that has exhibited protective efficacy in humans was the RV144 study completed in Th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Doran, Rachel C., Yu, Bin, Wright, Meredith, O'Rourke, Sara M., Yin, Lu, Richardson, Jennie M., Byrne, Gabriel, Mesa, Kathryn A., Berman, Phillip W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182045/ https://www.ncbi.nlm.nih.gov/pubmed/30344523 http://dx.doi.org/10.3389/fimmu.2018.02313

Ejemplares similares

Antigen processing sites in gp120 are conserved across HIV virus clades
por: Yu, B, et al.
Publicado: (2012)

Glycan modifications to the gp120 immunogens used in the RV144 vaccine trial improve binding to broadly neutralizing antibodies
por: Doran, Rachel C., et al.
Publicado: (2018)

CRISPR/Cas9 gene editing for the creation of an MGAT1-deficient CHO cell line to control HIV-1 vaccine glycosylation
por: Byrne, Gabriel, et al.
Publicado: (2018)

Unusual Cysteine Content in V1 Region of gp120 From an Elite Suppressor That Produces Broadly Neutralizing Antibodies
por: Hutchinson, Jennie M., et al.
Publicado: (2019)

Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production
por: O’Rourke, Sara M., et al.
Publicado: (2018)

Rapid development of cross-clade neutralizing antibody responses after clade B gp120/gp140 protein priming and clade c gp140 protein boosting
por: Spearman, P, et al.
Publicado: (2012)

Extensive glycoform heterogeneity in the gp120 envelope proteins used in the RV144 trial
por: Yu, B, et al.
Publicado: (2012)

Gene editing in CHO cells to prevent proteolysis and enhance glycosylation: Production of HIV envelope proteins as vaccine immunogens
por: Li, Sophia W., et al.
Publicado: (2020)

Characterization of a monoclonal antibody to a novel glycan-dependent epitope in the V1/V2 domain of the HIV-1 envelope protein, gp120
por: Doran, Rachel C., et al.
Publicado: (2014)

Glycoform and Net Charge Heterogeneity in gp120 Immunogens Used in HIV Vaccine Trials
por: Yu, Bin, et al.
Publicado: (2012)

Bispecific Anti-HIV Immunoadhesins That Bind Gp120 and Gp41 Have Broad and Potent HIV-Neutralizing Activity
por: Pincus, Seth H., et al.
Publicado: (2021)

Focusing the immune response on the V3 loop of HIV-1 gp120 induces cross-clade neutralizing
por: Zolla-Pazner, Susan, et al.
Publicado: (2006)

Glycans Flanking the Hypervariable Connecting Peptide between the A and B Strands of the V1/V2 Domain of HIV-1 gp120 Confer Resistance to Antibodies That Neutralize CRF01_AE Viruses
por: O’Rourke, Sara M., et al.
Publicado: (2015)

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-120 interface
por: Huang, Jinghe, et al.
Publicado: (2014)

Immunogenicity of the outer domain of a HIV-1 clade C gp120
por: Chen, Hongying, et al.
Publicado: (2007)

Eliciting neutralizing antibodies with gp120 outer domain
por: Qin, Y, et al.
Publicado: (2012)

Mapping epitopes on CRF01_AE viruses recognized by broadly neutralizing antibodies in sera from elite neutralizers from North America and Thailand
por: O'Rourke, SM, et al.
Publicado: (2012)

Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding
por: Panico, Maria, et al.
Publicado: (2016)

Geospatial HIV-1 subtype C gp120 sequence diversity and its predicted impact on broadly neutralizing antibody sensitivity
por: Sutar, Jyoti, et al.
Publicado: (2021)

A Human Antibody to the CD4 Binding Site of gp120 Capable of Highly Potent but Sporadic Cross Clade Neutralization of Primary HIV-1
por: Gach, Johannes S., et al.
Publicado: (2013)

Structural definition for a new modality of broad and potent antibody neutralization at the CD4-binding site on HIV-1 gp120
por: Zhou, T, et al.
Publicado: (2012)

Free Energy Perturbation Calculation of Relative Binding Free Energy between Broadly Neutralizing Antibodies and the gp120 Glycoprotein of HIV-1
por: Clark, Anthony J., et al.
Publicado: (2017)

P05-14 LB. Analysis of virus swarms to identify vaccine immunogens with improved exposure of epitopes recognized by broadly neutralizing antibodies
por: Berman, P, et al.
Publicado: (2009)

Allosteric Modulation of the HIV-1 gp120-gp41 Association Site by Adjacent gp120 Variable Region 1 (V1) N-Glycans Linked to Neutralization Sensitivity
por: Drummer, Heidi E., et al.
Publicado: (2013)

Structural definition of a conserved neutralization epitope on HIV-1 gp120
por: Zhou, Tongqing, et al.
Publicado: (2007)

Mutations in the V1 domain of Thai CRF01-AE viruses that confer sensitivity/resistance to broadly neutralizing antibodies
por: O'Rourke, S, et al.
Publicado: (2012)

CD169-Mediated Trafficking of HIV to Plasma Membrane Invaginations in Dendritic Cells Attenuates Efficacy of Anti-gp120 Broadly Neutralizing Antibodies
por: Akiyama, Hisashi, et al.
Publicado: (2015)

Mapping the immune response to the outer domain of a human immunodeficiency virus-1 clade C gp120
por: Chen, Hongying, et al.
Publicado: (2008)

Interaction of the gp120 V1V2 loop with a neighboring gp120 unit shields the HIV envelope trimer against cross-neutralizing antibodies
por: Rusert, Peter, et al.
Publicado: (2011)

Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and co-receptor binding sites of HIV-1 gp120
por: Matz, J, et al.
Publicado: (2012)

Correction: CD169-Mediated Trafficking of HIV to Plasma Membrane Invaginations in Dendritic Cells Attenuates Efficacy of Anti-gp120 Broadly Neutralizing Antibodies
Publicado: (2015)

MPER-specific antibodies induce gp120 shedding and irreversibly neutralize HIV-1
por: Ruprecht, Claudia R., et al.
Publicado: (2011)

HIV-1 Gp120 clade B/C induces a GRP78 driven cytoprotective mechanism in astrocytoma
por: López, Sheila N., et al.
Publicado: (2017)

Identification and Characterization of a Broadly Cross-Reactive HIV-1 Human Monoclonal Antibody That Binds to Both gp120 and gp41
por: Zhang, Mei-Yun, et al.
Publicado: (2012)

Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes
por: Strokappe, Nika M., et al.
Publicado: (2019)

Human immunodeficiency virus type 1 neutralization is determined by epitope exposure on the gp120 oligomer
Publicado: (1995)

Allosteric induction of the CD4-bound conformation of HIV-1 Gp120
por: Roitburd-Berman, Anna, et al.
Publicado: (2013)

Neutralization diversity of HIV-1 Indian subtype C envelopes obtained from cross sectional and followed up individuals against broadly neutralizing monoclonal antibodies having distinct gp120 specificities
por: Mullick, Ranajoy, et al.
Publicado: (2021)

HIV-1 envelope trimer elicits higher neutralizing antibody responses than monomeric gp120
por: Kovacs, JM, et al.
Publicado: (2012)

Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans
por: Julien, Jean-Philippe, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_7qq0jg2thdp8l37la9ilpmpb92