DNA Topoisomerase 1 Structure-BASED Design, Synthesis, Activity Evaluation and Molecular Simulations Study of New 7-Amide Camptothecin Derivatives Against Spodoptera frugiperda

Camptothecin and its derivatives (CPTs) have strong toxicity to eukaryotic cells by targeting their DNA topoisomerase 1 (Top1) protein and have been increasingly explored as potential pesticides for plant protection. However, the detailed structure-binding mechanism of the interactions between CPTs...

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Detalles Bibliográficos
Autores principales: Jiang, Zhiyan, Zhang, Zhijun, Cui, Gaofeng, Sun, Zhipeng, Song, Gaopeng, Liu, Yingqian, Zhong, Guohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182061/
https://www.ncbi.nlm.nih.gov/pubmed/30345269
http://dx.doi.org/10.3389/fchem.2018.00456

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