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Translocation kinetics and structural dynamics of ribosomes are modulated by the conformational plasticity of downstream pseudoknots
Downstream stable mRNA secondary structures can stall elongating ribosomes by impeding the concerted movements of tRNAs and mRNA on the ribosome during translocation. The addition of a downstream mRNA structure, such as a stem-loop or a pseudoknot, is essential to induce -1 programmed ribosomal fram...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182138/ https://www.ncbi.nlm.nih.gov/pubmed/30011005 http://dx.doi.org/10.1093/nar/gky636 |