p15(PAF) binding to PCNA modulates the DNA sliding surface

p15(PAF) is an oncogenic intrinsically disordered protein that regulates DNA replication and lesion bypass by interacting with the human sliding clamp PCNA. In the absence of DNA, p15(PAF) traverses the PCNA ring via an extended PIP-box that contacts the sliding surface. Here, we probed the atomic-s...

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Detalles Bibliográficos
Autores principales: De March, Matteo, Barrera-Vilarmau, Susana, Crespan, Emmanuele, Mentegari, Elisa, Merino, Nekane, Gonzalez-Magaña, Amaia, Romano-Moreno, Miguel, Maga, Giovanni, Crehuet, Ramon, Onesti, Silvia, Blanco, Francisco J, De Biasio, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182140/
https://www.ncbi.nlm.nih.gov/pubmed/30102405
http://dx.doi.org/10.1093/nar/gky723

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