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A two-nuclease pathway involving RNase H1 is required for primer removal at human mitochondrial OriL

The role of Ribonuclease H1 (RNase H1) during primer removal and ligation at the mitochondrial origin of light-strand DNA synthesis (OriL) is a key, yet poorly understood, step in mitochondrial DNA maintenance. Here, we reconstitute the replication cycle of L-strand synthesis in vitro using recombin...

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Detalles Bibliográficos
Autores principales:	Al-Behadili, Ali, Uhler, Jay P, Berglund, Anna-Karin, Peter, Bradley, Doimo, Mara, Reyes, Aurelio, Wanrooij, Sjoerd, Zeviani, Massimo, Falkenberg, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182146/ https://www.ncbi.nlm.nih.gov/pubmed/30102370 http://dx.doi.org/10.1093/nar/gky708

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