Double methylation of tRNA-U54 to 2′-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7

Sensing of nucleic acids for molecular discrimination between self and non-self is a challenging task for the innate immune system. RNA acts as a potent stimulus for pattern recognition receptors including in particular human Toll-like receptor 7 (TLR7). Certain RNA modifications limit potentially h...

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Detalles Bibliográficos
Autores principales: Keller, Patrick, Freund, Isabel, Marchand, Virginie, Bec, Guillaume, Huang, Raven, Motorin, Yuri, Eigenbrod, Tatjana, Dalpke, Alexander, Helm, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182150/
https://www.ncbi.nlm.nih.gov/pubmed/30102387
http://dx.doi.org/10.1093/nar/gky644

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