Growth-restricting effects of siRNA transfections: a largely deterministic combination of off-target binding and hybridization-independent competition

Perturbation of gene expression by means of synthetic small interfering RNAs (siRNAs) is a powerful way to uncover gene function. However, siRNA technology suffers from sequence-specific off-target effects and from limitations in knock-down efficiency. In this study, we assess a further problem: uni...

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Detalles Bibliográficos
Autores principales: Daga, Neha, Eicher, Simone, Kannan, Abhilash, Casanova, Alain, Low, Shyan H, Kreibich, Saskia, Andritschke, Daniel, Emmenlauer, Mario, Jenkins, Jeremy L, Hardt, Wolf-Dietrich, Greber, Urs F, Dehio, Christoph, von Mering, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182159/
https://www.ncbi.nlm.nih.gov/pubmed/30215772
http://dx.doi.org/10.1093/nar/gky798

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