miR-122, small RNA annealing and sequence mutations alter the predicted structure of the Hepatitis C virus 5′ UTR RNA to stabilize and promote viral RNA accumulation

Annealing of the liver-specific microRNA, miR-122, to the Hepatitis C virus (HCV) 5′ UTR is required for efficient virus replication. By using siRNAs to pressure escape mutations, 30 replication-competent HCV genomes having nucleotide changes in the conserved 5′ untranslated region (UTR) were identi...

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Detalles Bibliográficos
Autores principales: Amador-Cañizares, Yalena, Panigrahi, Mamata, Huys, Adam, Kunden, Rasika D, Adams, Halim M, Schinold, Michael J, Wilson, Joyce A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182169/
https://www.ncbi.nlm.nih.gov/pubmed/30053137
http://dx.doi.org/10.1093/nar/gky662

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