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SOX4 can redirect TGF-β-mediated SMAD3-transcriptional output in a context-dependent manner to promote tumorigenesis
Expression of the transcription factor SOX4 is often elevated in human cancers, where it generally correlates with tumor-progression and poor-disease outcome. Reduction of SOX4 expression results in both diminished tumor-incidence and metastasis. In breast cancer, TGF-β-mediated induction of SOX4 ha...
Autores principales: | Vervoort, Stephin J, Lourenço, Ana Rita, Tufegdzic Vidakovic, Ana, Mocholi, Enric, Sandoval, José L, Rueda, Oscar M, Frederiks, Cynthia, Pals, Cornelieke, Peeters, Janneke G C, Caldas, Carlos, Bruna, Alejandra, Coffer, Paul J |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182182/ https://www.ncbi.nlm.nih.gov/pubmed/30137431 http://dx.doi.org/10.1093/nar/gky755 |
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