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Myocyte Remodeling Due to Fibro-Fatty Infiltrations Influences Arrhythmogenicity
The onset of cardiac arrhythmias depends on the electrophysiological and structural properties of cardiac tissue. Electrophysiological remodeling of myocytes due to the presence of adipocytes constitutes a possibly important pathway in the pathogenesis of atrial fibrillation. In this paper we perfor...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182296/ https://www.ncbi.nlm.nih.gov/pubmed/30344493 http://dx.doi.org/10.3389/fphys.2018.01381 |
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author | De Coster, Tim Claus, Piet Seemann, Gunnar Willems, Rik Sipido, Karin R. Panfilov, Alexander V. |
author_facet | De Coster, Tim Claus, Piet Seemann, Gunnar Willems, Rik Sipido, Karin R. Panfilov, Alexander V. |
author_sort | De Coster, Tim |
collection | PubMed |
description | The onset of cardiac arrhythmias depends on the electrophysiological and structural properties of cardiac tissue. Electrophysiological remodeling of myocytes due to the presence of adipocytes constitutes a possibly important pathway in the pathogenesis of atrial fibrillation. In this paper we perform an in-silico study of the effect of such myocyte remodeling on the onset of atrial arrhythmias and study the dynamics of arrhythmia sources—spiral waves. We use the Courtemanche model for atrial myocytes and modify their electrophysiological properties based on published cellular electrophysiological measurements in myocytes co-cultered with adipocytes (a 69–87 % increase in APD(90) and an increase of the RMP by 2.5–5.5 mV). In a generic 2D setup we show that adipose tissue remodeling substantially affects the spiral wave dynamics resulting in complex arrhythmia and such arrhythmia can be initiated under high frequency pacing if the size of the remodeled tissue is sufficiently large. These results are confirmed in simulations with an anatomically accurate model of the human atria. |
format | Online Article Text |
id | pubmed-6182296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61822962018-10-19 Myocyte Remodeling Due to Fibro-Fatty Infiltrations Influences Arrhythmogenicity De Coster, Tim Claus, Piet Seemann, Gunnar Willems, Rik Sipido, Karin R. Panfilov, Alexander V. Front Physiol Physiology The onset of cardiac arrhythmias depends on the electrophysiological and structural properties of cardiac tissue. Electrophysiological remodeling of myocytes due to the presence of adipocytes constitutes a possibly important pathway in the pathogenesis of atrial fibrillation. In this paper we perform an in-silico study of the effect of such myocyte remodeling on the onset of atrial arrhythmias and study the dynamics of arrhythmia sources—spiral waves. We use the Courtemanche model for atrial myocytes and modify their electrophysiological properties based on published cellular electrophysiological measurements in myocytes co-cultered with adipocytes (a 69–87 % increase in APD(90) and an increase of the RMP by 2.5–5.5 mV). In a generic 2D setup we show that adipose tissue remodeling substantially affects the spiral wave dynamics resulting in complex arrhythmia and such arrhythmia can be initiated under high frequency pacing if the size of the remodeled tissue is sufficiently large. These results are confirmed in simulations with an anatomically accurate model of the human atria. Frontiers Media S.A. 2018-10-04 /pmc/articles/PMC6182296/ /pubmed/30344493 http://dx.doi.org/10.3389/fphys.2018.01381 Text en Copyright © 2018 De Coster, Claus, Seemann, Willems, Sipido and Panfilov. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology De Coster, Tim Claus, Piet Seemann, Gunnar Willems, Rik Sipido, Karin R. Panfilov, Alexander V. Myocyte Remodeling Due to Fibro-Fatty Infiltrations Influences Arrhythmogenicity |
title | Myocyte Remodeling Due to Fibro-Fatty Infiltrations Influences Arrhythmogenicity |
title_full | Myocyte Remodeling Due to Fibro-Fatty Infiltrations Influences Arrhythmogenicity |
title_fullStr | Myocyte Remodeling Due to Fibro-Fatty Infiltrations Influences Arrhythmogenicity |
title_full_unstemmed | Myocyte Remodeling Due to Fibro-Fatty Infiltrations Influences Arrhythmogenicity |
title_short | Myocyte Remodeling Due to Fibro-Fatty Infiltrations Influences Arrhythmogenicity |
title_sort | myocyte remodeling due to fibro-fatty infiltrations influences arrhythmogenicity |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182296/ https://www.ncbi.nlm.nih.gov/pubmed/30344493 http://dx.doi.org/10.3389/fphys.2018.01381 |
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