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Mean platelet volume to platelet count ratio as a laboratory indicator of mortality in pneumonia following ischemic stroke

BACKGROUND: Platelets have a vital role in antimicrobial host defenses. The objective of this study was to evaluate if increased mean platelet volume to platelet count (MPV/PC) ratio in acute ischemic stroke patients complicated with pneumonia was associated with increased mortality risk. METHODS: T...

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Autores principales: Nageeb, Rania S., Abozaid, Mohammed M. N., Nageeb, Ghada S., Omran, Alaa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182329/
https://www.ncbi.nlm.nih.gov/pubmed/30363799
http://dx.doi.org/10.1186/s41983-018-0028-9
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author Nageeb, Rania S.
Abozaid, Mohammed M. N.
Nageeb, Ghada S.
Omran, Alaa A.
author_facet Nageeb, Rania S.
Abozaid, Mohammed M. N.
Nageeb, Ghada S.
Omran, Alaa A.
author_sort Nageeb, Rania S.
collection PubMed
description BACKGROUND: Platelets have a vital role in antimicrobial host defenses. The objective of this study was to evaluate if increased mean platelet volume to platelet count (MPV/PC) ratio in acute ischemic stroke patients complicated with pneumonia was associated with increased mortality risk. METHODS: The current study was conducted at Zagazig University Hospitals. It included 500 acute ischemic stroke patients classified as group 1 that included 51 patients complicated with pneumonia after admission and group 2 that included the remaining 449 patients. Clinical assessment was carried out to exclude comorbid medical illnesses likely to interfere with platelet function or morphology. Laboratory investigations including MPV/PC ratio and brain imaging were carried out for all patients. RESULTS: There was a significant difference between both groups regarding age, National Institutes of Health Stroke Scale (NIHSS) score, and mortality within 30 days (p = 0.02, 0.03, 0.01). There was a significant difference between survivors and non-survivors of group 1 regarding to pneumonia severity index (PSI) classes IV and V (p = 0.01 and 0.02, respectively). Also, there was a significant difference regarding confusion, urea ≥ 7 mmol/L, respiratory rater ≥ 30 breaths/min, systolic blood pressure ≤ 90 mmHg or diastolic blood pressure ≤ 60 mmHg, and age ≥ 65 years at pneumonia occurrence (CURB-65) scores 3, 4, and 5 (p = 0.03, 0.02, and 0.01, respectively). Moreover, there was a significant difference regarding decreased GCS score at pneumonia occurrence, higher NIHSS scores, PSI, and higher MPV/PC ratio (p = 0.01, 0.01, 0.028, and 0.01, respectively). Age > 65 years, need for mechanical ventilation, GCS score of > 9, PSI class ≥ IV, CURB-65 scores ≥ 3, and increased MPV/PC ratio were all significantly associated with 30-day mortality in group 1 (p = 0.03, 0.01, 0.001, 0.04, 0.01, and 0.03, respectively). The predictors of 30-day mortality risk factors were GCS less than 9, increased MPV/PC ratio, and CURB-65 scores ≥ 3 (p = 0.001, 0.05, and 0.01, respectively). CONCLUSIONS: Once pneumonia develops, MPV/PC ratio could be considered a significant laboratory indicator of 30-day mortality.
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spelling pubmed-61823292018-10-22 Mean platelet volume to platelet count ratio as a laboratory indicator of mortality in pneumonia following ischemic stroke Nageeb, Rania S. Abozaid, Mohammed M. N. Nageeb, Ghada S. Omran, Alaa A. Egypt J Neurol Psychiatr Neurosurg Research BACKGROUND: Platelets have a vital role in antimicrobial host defenses. The objective of this study was to evaluate if increased mean platelet volume to platelet count (MPV/PC) ratio in acute ischemic stroke patients complicated with pneumonia was associated with increased mortality risk. METHODS: The current study was conducted at Zagazig University Hospitals. It included 500 acute ischemic stroke patients classified as group 1 that included 51 patients complicated with pneumonia after admission and group 2 that included the remaining 449 patients. Clinical assessment was carried out to exclude comorbid medical illnesses likely to interfere with platelet function or morphology. Laboratory investigations including MPV/PC ratio and brain imaging were carried out for all patients. RESULTS: There was a significant difference between both groups regarding age, National Institutes of Health Stroke Scale (NIHSS) score, and mortality within 30 days (p = 0.02, 0.03, 0.01). There was a significant difference between survivors and non-survivors of group 1 regarding to pneumonia severity index (PSI) classes IV and V (p = 0.01 and 0.02, respectively). Also, there was a significant difference regarding confusion, urea ≥ 7 mmol/L, respiratory rater ≥ 30 breaths/min, systolic blood pressure ≤ 90 mmHg or diastolic blood pressure ≤ 60 mmHg, and age ≥ 65 years at pneumonia occurrence (CURB-65) scores 3, 4, and 5 (p = 0.03, 0.02, and 0.01, respectively). Moreover, there was a significant difference regarding decreased GCS score at pneumonia occurrence, higher NIHSS scores, PSI, and higher MPV/PC ratio (p = 0.01, 0.01, 0.028, and 0.01, respectively). Age > 65 years, need for mechanical ventilation, GCS score of > 9, PSI class ≥ IV, CURB-65 scores ≥ 3, and increased MPV/PC ratio were all significantly associated with 30-day mortality in group 1 (p = 0.03, 0.01, 0.001, 0.04, 0.01, and 0.03, respectively). The predictors of 30-day mortality risk factors were GCS less than 9, increased MPV/PC ratio, and CURB-65 scores ≥ 3 (p = 0.001, 0.05, and 0.01, respectively). CONCLUSIONS: Once pneumonia develops, MPV/PC ratio could be considered a significant laboratory indicator of 30-day mortality. Springer Berlin Heidelberg 2018-09-26 2018 /pmc/articles/PMC6182329/ /pubmed/30363799 http://dx.doi.org/10.1186/s41983-018-0028-9 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Nageeb, Rania S.
Abozaid, Mohammed M. N.
Nageeb, Ghada S.
Omran, Alaa A.
Mean platelet volume to platelet count ratio as a laboratory indicator of mortality in pneumonia following ischemic stroke
title Mean platelet volume to platelet count ratio as a laboratory indicator of mortality in pneumonia following ischemic stroke
title_full Mean platelet volume to platelet count ratio as a laboratory indicator of mortality in pneumonia following ischemic stroke
title_fullStr Mean platelet volume to platelet count ratio as a laboratory indicator of mortality in pneumonia following ischemic stroke
title_full_unstemmed Mean platelet volume to platelet count ratio as a laboratory indicator of mortality in pneumonia following ischemic stroke
title_short Mean platelet volume to platelet count ratio as a laboratory indicator of mortality in pneumonia following ischemic stroke
title_sort mean platelet volume to platelet count ratio as a laboratory indicator of mortality in pneumonia following ischemic stroke
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182329/
https://www.ncbi.nlm.nih.gov/pubmed/30363799
http://dx.doi.org/10.1186/s41983-018-0028-9
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