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A126 in the active site and TI167/168 in the TI loop are essential determinants of the substrate specificity of PTEN
PTEN prevents tumor genesis by antagonizing the PI3 kinase/Akt pathway through D3 site phosphatase activity toward PI(3,4)P(2) and PI(3,4,5)P(3). The structural determinants of this important specificity remain unknown. Interestingly, PTEN shares remarkable homology to voltage-sensitive phosphatases...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182344/ https://www.ncbi.nlm.nih.gov/pubmed/29987362 http://dx.doi.org/10.1007/s00018-018-2867-z |