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Evaluation of Diagnostic Efficiency of Alpha-Fetoprotein in Patients with Liver Cirrhosis and Hepatocellular Carcinoma: Single-Center Experience

BACKGROUND: AFP serum levels are considered as diagnostic and specific for hepatocellular carcinoma (HCC) in patients with liver cirrhosis (LC). AIM: This study aimed to examine the diagnostic value of AFP in the distinguishing of patients with HCC from patients with LC, and to analyse the potential...

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Autores principales: Mehinovic, Lejla, Islamagic, Erna, Husic-Selimovic, Azra, Kurtovic-Kozaric, Amina, Vukobrat-Bijedic, Zora, Suljevic, Damir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182518/
https://www.ncbi.nlm.nih.gov/pubmed/30337985
http://dx.doi.org/10.3889/oamjms.2018.344
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author Mehinovic, Lejla
Islamagic, Erna
Husic-Selimovic, Azra
Kurtovic-Kozaric, Amina
Vukobrat-Bijedic, Zora
Suljevic, Damir
author_facet Mehinovic, Lejla
Islamagic, Erna
Husic-Selimovic, Azra
Kurtovic-Kozaric, Amina
Vukobrat-Bijedic, Zora
Suljevic, Damir
author_sort Mehinovic, Lejla
collection PubMed
description BACKGROUND: AFP serum levels are considered as diagnostic and specific for hepatocellular carcinoma (HCC) in patients with liver cirrhosis (LC). AIM: This study aimed to examine the diagnostic value of AFP in the distinguishing of patients with HCC from patients with LC, and to analyse the potential correlation between AFP levels and liver disease stages. MATERIAL AND METHODS: Fifty patients with LC and fifty patients with HCC were included in this study. The majority of the patients were males, while the HBV aetiology was dominant. RESULTS: Significant differences between LC and HCC patients were detected for AST, ALT, GGT, bilirubin, AFP and AP. Patients with HCC had higher AFP values compared to LC. There was no significant correlation between the size of the tumour lesion and serum AFP levels. A positive correlation between AFP concentration and GGT activity was determined, as was the negative correlation between AFP and age of the subjects. The AFP value of 23.34 ng/m showed high sensitivity (84%) and specificity (82%). CONCLUSION: The size of the surface below the ROC curve (AUC) was 0.877 (0.80-0.95), which makes AFP a good biomarker and this diagnostic test is sufficient to separate patients with HCC and LC.
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spelling pubmed-61825182018-10-18 Evaluation of Diagnostic Efficiency of Alpha-Fetoprotein in Patients with Liver Cirrhosis and Hepatocellular Carcinoma: Single-Center Experience Mehinovic, Lejla Islamagic, Erna Husic-Selimovic, Azra Kurtovic-Kozaric, Amina Vukobrat-Bijedic, Zora Suljevic, Damir Open Access Maced J Med Sci Clinical Science BACKGROUND: AFP serum levels are considered as diagnostic and specific for hepatocellular carcinoma (HCC) in patients with liver cirrhosis (LC). AIM: This study aimed to examine the diagnostic value of AFP in the distinguishing of patients with HCC from patients with LC, and to analyse the potential correlation between AFP levels and liver disease stages. MATERIAL AND METHODS: Fifty patients with LC and fifty patients with HCC were included in this study. The majority of the patients were males, while the HBV aetiology was dominant. RESULTS: Significant differences between LC and HCC patients were detected for AST, ALT, GGT, bilirubin, AFP and AP. Patients with HCC had higher AFP values compared to LC. There was no significant correlation between the size of the tumour lesion and serum AFP levels. A positive correlation between AFP concentration and GGT activity was determined, as was the negative correlation between AFP and age of the subjects. The AFP value of 23.34 ng/m showed high sensitivity (84%) and specificity (82%). CONCLUSION: The size of the surface below the ROC curve (AUC) was 0.877 (0.80-0.95), which makes AFP a good biomarker and this diagnostic test is sufficient to separate patients with HCC and LC. Republic of Macedonia 2018-09-24 /pmc/articles/PMC6182518/ /pubmed/30337985 http://dx.doi.org/10.3889/oamjms.2018.344 Text en Copyright: © 2018 Lejla Mehinovic, Erna Islamagic, Azra Husic-Selimovic, Amina Kurtovic-Kozaric, Zora Vukobrat-Bijedic, Damir Suljevic. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
spellingShingle Clinical Science
Mehinovic, Lejla
Islamagic, Erna
Husic-Selimovic, Azra
Kurtovic-Kozaric, Amina
Vukobrat-Bijedic, Zora
Suljevic, Damir
Evaluation of Diagnostic Efficiency of Alpha-Fetoprotein in Patients with Liver Cirrhosis and Hepatocellular Carcinoma: Single-Center Experience
title Evaluation of Diagnostic Efficiency of Alpha-Fetoprotein in Patients with Liver Cirrhosis and Hepatocellular Carcinoma: Single-Center Experience
title_full Evaluation of Diagnostic Efficiency of Alpha-Fetoprotein in Patients with Liver Cirrhosis and Hepatocellular Carcinoma: Single-Center Experience
title_fullStr Evaluation of Diagnostic Efficiency of Alpha-Fetoprotein in Patients with Liver Cirrhosis and Hepatocellular Carcinoma: Single-Center Experience
title_full_unstemmed Evaluation of Diagnostic Efficiency of Alpha-Fetoprotein in Patients with Liver Cirrhosis and Hepatocellular Carcinoma: Single-Center Experience
title_short Evaluation of Diagnostic Efficiency of Alpha-Fetoprotein in Patients with Liver Cirrhosis and Hepatocellular Carcinoma: Single-Center Experience
title_sort evaluation of diagnostic efficiency of alpha-fetoprotein in patients with liver cirrhosis and hepatocellular carcinoma: single-center experience
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182518/
https://www.ncbi.nlm.nih.gov/pubmed/30337985
http://dx.doi.org/10.3889/oamjms.2018.344
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