Current and Emerging Treatment Modalities for Leber’s Hereditary Optic Neuropathy: A Review of the Literature

INTRODUCTION: The purpose of this review is to present the current and emerging treatment alternatives for Leber’s hereditary optic neuropathy (LHON), emphasizing the most recent use of idebenone and stem cells or gene therapy. METHODS: A comprehensive literature review was performed at the PubMed d...

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Autores principales: Theodorou-Kanakari, Anna, Karampitianis, Spyridon, Karageorgou, Vasiliki, Kampourelli, Eleni, Kapasakis, Efstathios, Theodossiadis, Panagiotis, Chatziralli, Irini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182630/
https://www.ncbi.nlm.nih.gov/pubmed/30173326
http://dx.doi.org/10.1007/s12325-018-0776-z
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author Theodorou-Kanakari, Anna
Karampitianis, Spyridon
Karageorgou, Vasiliki
Kampourelli, Eleni
Kapasakis, Efstathios
Theodossiadis, Panagiotis
Chatziralli, Irini
author_facet Theodorou-Kanakari, Anna
Karampitianis, Spyridon
Karageorgou, Vasiliki
Kampourelli, Eleni
Kapasakis, Efstathios
Theodossiadis, Panagiotis
Chatziralli, Irini
author_sort Theodorou-Kanakari, Anna
collection PubMed
description INTRODUCTION: The purpose of this review is to present the current and emerging treatment alternatives for Leber’s hereditary optic neuropathy (LHON), emphasizing the most recent use of idebenone and stem cells or gene therapy. METHODS: A comprehensive literature review was performed at the PubMed database regarding the various treatment modalities for LHON. RESULTS: Treatment modalities for LHON include nutritional supplements, activators of mitochondrial biogenesis, brimonidine, and symptomatic and supportive treatment, but nowadays attention is being paid to idebenone and gene therapy or stem cells. CONCLUSION: The treatment of LHON remains challenging, given the nature of the disease and its prognosis.
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spelling pubmed-61826302018-10-24 Current and Emerging Treatment Modalities for Leber’s Hereditary Optic Neuropathy: A Review of the Literature Theodorou-Kanakari, Anna Karampitianis, Spyridon Karageorgou, Vasiliki Kampourelli, Eleni Kapasakis, Efstathios Theodossiadis, Panagiotis Chatziralli, Irini Adv Ther Review INTRODUCTION: The purpose of this review is to present the current and emerging treatment alternatives for Leber’s hereditary optic neuropathy (LHON), emphasizing the most recent use of idebenone and stem cells or gene therapy. METHODS: A comprehensive literature review was performed at the PubMed database regarding the various treatment modalities for LHON. RESULTS: Treatment modalities for LHON include nutritional supplements, activators of mitochondrial biogenesis, brimonidine, and symptomatic and supportive treatment, but nowadays attention is being paid to idebenone and gene therapy or stem cells. CONCLUSION: The treatment of LHON remains challenging, given the nature of the disease and its prognosis. Springer Healthcare 2018-09-01 2018 /pmc/articles/PMC6182630/ /pubmed/30173326 http://dx.doi.org/10.1007/s12325-018-0776-z Text en © The Author(s) 2018 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Theodorou-Kanakari, Anna
Karampitianis, Spyridon
Karageorgou, Vasiliki
Kampourelli, Eleni
Kapasakis, Efstathios
Theodossiadis, Panagiotis
Chatziralli, Irini
Current and Emerging Treatment Modalities for Leber’s Hereditary Optic Neuropathy: A Review of the Literature
title Current and Emerging Treatment Modalities for Leber’s Hereditary Optic Neuropathy: A Review of the Literature
title_full Current and Emerging Treatment Modalities for Leber’s Hereditary Optic Neuropathy: A Review of the Literature
title_fullStr Current and Emerging Treatment Modalities for Leber’s Hereditary Optic Neuropathy: A Review of the Literature
title_full_unstemmed Current and Emerging Treatment Modalities for Leber’s Hereditary Optic Neuropathy: A Review of the Literature
title_short Current and Emerging Treatment Modalities for Leber’s Hereditary Optic Neuropathy: A Review of the Literature
title_sort current and emerging treatment modalities for leber’s hereditary optic neuropathy: a review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182630/
https://www.ncbi.nlm.nih.gov/pubmed/30173326
http://dx.doi.org/10.1007/s12325-018-0776-z
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